22821-86-9

Basic information

• Product Name: Benzene, 1,4-bis(methylsulfonyl)-
• CAS NO: 22821-86-9
• Molecular Formula: C8H10O4S2
• Molecular Weight: 234.297
• Mol File: 22821-86-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1,4-bis(methylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,4-bis(methylsulfonyl)-(22821-86-9)
• EPA Substance Registry System: Benzene, 1,4-bis(methylsulfonyl)-(22821-86-9)

Safety Data

• Hazardous Substances Data: 22821-86-9(Hazardous Substances Data)

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 20277-69-4 sodium methansulfinate 
• 82964-91-8 4-methylsulfinylbenzenesulfonyl chloride 
• 624-39-5 benzene-1,4-dithiol 
• 3814-25-3 4-(methylsulfonyl)benzenethiol 
• 636-98-6 p-nitrobenzene iodide 
• 74-88-4 methyl iodide 
• 699-20-7 1,4-Bis(methylthio)benzene 
• 7732-18-5 water 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 22821-88-1 4-(methylsulfonyl)-benzenesulfinic acid 
• 64-17-5 ethanol 
• 147139-87-5 benzene-1,4-disulfinic acid 

Downstream Products

• 3517-90-6 p-anisyl methyl sulfone 

Relevant articles and documents

Meta -Non-flat substituents: A novel molecular design to improve aqueous solubility in small molecule drug discovery

Aqueous solubility is a key requirement for small-molecule drug candidates. Here, we investigated the regioisomer-physicochemical property relationships of disubstituted benzenes. We found that meta-isomers bearing non-flat substituents tend to possess the lowest melting point and the highest thermodynamic aqueous solubility among the regioisomers. The examination of pharmaceutical compounds containing a disubstituted benzene moiety supported the idea that the introduction of a non-flat substituent at the meta position of a benzene substructure would be a promising approach for medicinal chemists aiming to improve the thermodynamic aqueous solubility of drug candidates, even though it might not be universally effective. This journal is

An Efficient Copper Catalyst for the Formation of Sulfones from Sulfinic Acid Salts and Aryl Iodides

(Matrix Presented) A novel copper-catalyzed method for the coupling of sulfinic acid salts and aryl iodides is described. A variety of methyl and diaryl sulfones have been formed in excellent yields.