228267-27-4Relevant articles and documents
Synthesis of J-111,347, a novel 1β-methylcarbapenem with broad-spectrum antibacterial activity
Imamura, Hideaki,Ohtake, Norikazu,Sakuraba, Shunji,Shimizu, Aya,Yamada, Koji,Morishima, Hajime
, p. 310 - 311 (2000)
Synthesis of J-111,347 (1), a new 1β-methylcarbapenem with broad- spectrum antibacterial activity including that against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, was achieved via diastereoselective preparation of a side-chain thiol 3 from an optically active (R)3,4-dihydroxybutanal 4.
Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio- 1β-methylcarbapenems. Part 1:J-111,347 and related compounds
Imamura, Hideaki,Ohtake, Norikazu,Shimizu, Aya,Jona, Hideki,Sato, Hiroki,Nagano, Rie,Ushijima, Ryosuke,Yamada, Koji,Hashizume, Terutaka,Morishima, Hajime
, p. 109 - 113 (2007/10/03)
1β-Methylcarbapenems having various 3,5-disubstituted pyrrolidinylthio- side chains at C-2 were designed and synthesized. Evaluation of their antibacterial activities indicated that J-111,347 (1a) is the first example of an extremely broad spectrum antibiotic showing activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa.