228575-98-2

Basic information

• Product Name: Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-
• CAS NO: 228575-98-2
• Molecular Formula: C16H11F3N2O
• Molecular Weight: 304.271
• Mol File: 228575-98-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-(228575-98-2)
• EPA Substance Registry System: Acetamide, N-[2-[(2-aminophenyl)ethynyl]phenyl]-2,2,2-trifluoro-(228575-98-2)

Safety Data

• Hazardous Substances Data: 228575-98-2(Hazardous Substances Data)

Upstream product

• 52670-38-9 2-ethynylaniline 
• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 

Downstream Products

• 128103-11-7 12-phenylindolo[1,2-c]quinazolin-6(5H)-one 

Relevant articles and documents

Synthesis of indolo[1,2-c]quinazolines from 2-alkynylaniline derivatives through Pd-catalyzed indole formation/cyclization with N,N-dimethylformamide dimethyl acetal

An efficient strategy for the synthesis of 6-unsubstituted indolo[1,2-c]quinazolines is described. The Pd-catalyzed reaction of o-(oaminophenylethynyl) trifluoroacetanilides with Ar-B(OH)2 afforded 2-(o-aminophenyl)-3-arylindoles, that were converted to 1

2-(o-aminoaryl)indole derivatives via the coupling-cyclization of o-alkynylanilines with o-halotrifluoroacetanilides in the presence of a palladium catalyst

The reaction of o-ethynylanilines with o-halotrifluoroacetanilides in the presence of PdCl2(PPh3)2 and Et3N in DMF at 90 °C affords 2-(o-trifluoroacetamidoaryl)indoles. The presence of the free amino group was found to play a crucial role in favoring the cyclization step.