228579-19-9Relevant articles and documents
Aryloxazolidinediones: Identification of potent orally active PPAR dual α/γ agonists
Desai, Ranjit C.,Gratale, Dominick F.,Han, Wei,Koyama, Hiroo,Metzger, Edward,Lombardo, Victoria K.,MacNaul, Karen L.,Doebber, Thomas W.,Berger, Joel P.,Leung, Kwan,Franklin, Ronald,Moller, David E.,Heck, James V.,Sahoo, Soumya P.
, p. 3541 - 3544 (2007/10/03)
A series of novel aryloxazolidine-2,4-diones was synthesized. A structure-activity relationship study of these compounds led to the identification of potent, orally active PPAR dual α/γ agonists. Based on the results of efficacy studies in the db/db mice
