22863-60-1Relevant articles and documents
Asymmetric Synthesis of 3,3′-Piperidinoyl Spirooxindoles and Discovery of Stereospecific Cycloadducts as Novel Hedgehog Pathway Modulators
Flegel, Jana,Heitkamp, Franziska,Kumar, Kamal,Otte, Felix,Pergomet, Jorgelina L.,Rehan, Mohammad,Strohmann, Carsten
supporting information, p. 3140 - 3152 (2020/09/07)
An enantioselective hetero-Diels-Alder reaction of alkylidene oxindoles and 2-aza-3-silyloxy-1,3-butadienes, catalyzed by divalent transition metal complexes with N, N ′-dioxide ligands offered an efficient access to natural-product-based 3,3′-piperidinoyl spirooxindole class of small molecules. exo -Cycloadducts formed via stereospecific cycloaddition with Z -olefin displayed potent activity in modulation of hedgehog pathway.
Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines
Monteiro, ?ngelo,Gon?alves, Lídia M.,Santos, Maria M.M.
, p. 266 - 272 (2014/05/06)
A series of novel spiropyrazoline oxindole derivatives was synthesized by 1,3-dipolar cycloaddition reaction. The compounds were screened for their in vitro cytotoxic activity against MCF-7 breast cancer cell line (estrogen receptor positive (ER+) and hum
