229171-07-7 Usage
Description
1H-Pyrazole, 4-iodo-1-(phenylmethoxy)is an organic compound characterized by the presence of a pyrazole ring with an iodine atom at the 4-position and a phenylmethoxy group at the 1-position. This molecule is known for its potential applications in the synthesis of various chemical compounds and pharmaceuticals.
Uses
1. Used in Pharmaceutical Synthesis:
1H-Pyrazole, 4-iodo-1-(phenylmethoxy)is used as an intermediate in the synthesis of amines and amino acids containing the pyrazole nucleus. Its unique structure allows for the development of novel bioactive molecules with potential applications in the pharmaceutical industry.
2. Used in the Synthesis of Aldose Reductase Inhibitors:
1H-Pyrazole, 4-iodo-1-(phenylmethoxy)is used as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitors. Aldose reductase inhibitors are important in the treatment of diabetic complications, and this compound contributes to the development of more effective inhibitors with improved pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 229171-07-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,9,1,7 and 1 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 229171-07:
(8*2)+(7*2)+(6*9)+(5*1)+(4*7)+(3*1)+(2*0)+(1*7)=127
127 % 10 = 7
So 229171-07-7 is a valid CAS Registry Number.
229171-07-7Relevant articles and documents
N-hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands
Clausen, Rasmus P.,Christensen, Caspar,Hansen, Kasper B.,Greenwood, Jeremy R.,J?rgensen, Lars,Micale, Nicola,Madsen, Jens Christian,Nielsen, Birgitte,Egebjerg, Jan,Br?uner-Osborne, Hans,Traynelis, Stephen F.,Kristensen, Jesper L.
scheme or table, p. 4179 - 4187 (2009/05/26)
A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized, and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that thes
Novel anionic annelation tactics for construction of fused heteroaromatic frameworks. 1. Synthesis of 4-substituted pyrazolo[4,3-c]quinolines, 9-substituted pyrazolo[3,4-c]quinolines, and 1,4-dihydrochromeno[4,3-c]pyrazoles
Pawlas,Vedso,Jakobsen,Huusfeldt,Begtrup
, p. 4214 - 4219 (2007/10/03)
4-Substituted pyrazolo[4,3-c]quinolines 4a-i and 6a-b were prepared from pyrazole 3 whereas 9-substituted pyrazolo[3,4-c]quinolines 9a-d and 17 were prepared from pyrazole 13 utilizing anionic annelation techniques. 1,4-Dihydrochromeno[4,3- c]pyrazoles 7a-c were accessed from pyrazole 3, extending the method for the synthesis of 4a-i.
