229182-32-5

Basic information

• Product Name: (R)-5--3-(4-chlorophenyl)pentanoic acid
• Synonyms: (R)-5--3-(4-chlorophenyl)pentanoic acid
• CAS NO: 229182-32-5
• Molecular Weight: 327.808
• Mol File: 229182-32-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-5--3-(4-chlorophenyl)pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5--3-(4-chlorophenyl)pentanoic acid(229182-32-5)
• EPA Substance Registry System: (R)-5--3-(4-chlorophenyl)pentanoic acid(229182-32-5)

Safety Data

• Hazardous Substances Data: 229182-32-5(Hazardous Substances Data)

Upstream product

• 128372-89-4 6-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 229182-28-9 (4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone 
• 229182-29-0 (R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-2-piperidinone 

Relevant articles and documents

Rhodium/diene-catalyzed asymmetric arylation of N-Boc-protected α,β-unsaturated δ-lactam with arylboronic acids: Enantioselective synthesis of 4-aryl-2-piperidinones

Utilizing toluene/isopropanol (20:1 to 40:1) as a solvent and KHF 2 as an additive, the rhodium/diene-catalyzed asymmetric arylation (RCAA) reaction of arylboronic acids to N-Boc-protected α,β- unsaturated δ-lactam proceeded smoothly to afford chiral 4-aryl-2-piperidinones with high to excellent yields (up to 94%) and enantioselectivities (up to >99% ee). Further conversion of adduct (R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-2-piperidone to (R)-Homobaclofen hydrochloride was also presented.