22921-89-7

Basic information

• Product Name: 3-Buten-2-one, 4-phenyl-, phenylhydrazone
• CAS NO: 22921-89-7
• Molecular Formula: C16H16N2
• Molecular Weight: 236.316
• Mol File: 22921-89-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-Buten-2-one, 4-phenyl-, phenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-one, 4-phenyl-, phenylhydrazone(22921-89-7)
• EPA Substance Registry System: 3-Buten-2-one, 4-phenyl-, phenylhydrazone(22921-89-7)

Safety Data

• Hazardous Substances Data: 22921-89-7(Hazardous Substances Data)

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 127-09-3 sodium acetate 
• 100-63-0 phenylhydrazine 
• 100-52-7 benzaldehyde 
• 1896-62-4 (E)-benzalacetone 
• 17488-65-2 4-phenylbut-3-en-2-ol 
• 17537-36-9 bis-(1-methyl-3-phenyl-allylidene)-hydrazine 

Downstream Products

• 2887-98-1 benzalacetone oxime 
• 22374-89-6 (RS)-1-methyl-3-phenylpropylamine 
• 3729-90-6 3-methyl-1,5-diphenyl-1H-pyrazole 
• 39259-45-5 benzylacetone phenylhydrazone 
• 94206-50-5 4-bromo-3-methyl-1,5-diphenyl-1H-pyrazole 
• 1428979-43-4 3-methyl-1,5-diphenyl-4-(phenylethynyl)-1H-pyrazole 
• 1428979-45-6 N-tert-butyl-3-methyl-1,5-diphenyl-1H-pyrazole-4-carboxamide 
• 1207963-45-8 (S)-3-methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 2515-46-0 (R)-3-methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 2515-46-0 3-methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 5468-31-5 benzylidenacetone semicarbazone 
• 122-57-6 1-Phenylbut-1-en-3-one 

Relevant articles and documents

Synthesis and antibacterial activity of some new hydrazones

New hydrazone derivatives were synthesized by the condensation of some selected heteroaromatic hydrazines with appropriate aromatic ketones at high temperature (100 °C). The structures of the synthesized compounds were established by elemental (CHN) and spectral (IR, 1HNMR, and Mass) analysis. The synthesized compounds were screened for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Proteus mirabilis) activities, which reveal that all the compounds possess activity against all the tested organisms.

Copper-catalyzed aerobic C(sp2)-H functionalization for C-N bond formation: Synthesis of pyrazoles and indazoles

A simple, practical, and highly efficient synthesis of pyrazoles and indazoles via copper-catalyzed direct aerobic oxidative C(sp2)-H amination has been reported herein. This process tolerated a variety of functional groups under mild conditions. Further diversification of pyrazoles was also investigated, which provided its potential for drug discovery.

Larvicidal studies of chalcones and their derivatives

Chalcone (1,3-diphenyl-2-propen-1-one) is considered as the lead compound among all the chalcone type compounds used for the larvicidal studies, as it has the highest toxicity against the larvae of Culex quinquefasciatus. 4-Phenylbut-3-en-2-one, where a methyl group replaces the phenyl group of chalcone, is less active than chalcone; but still has higher activity than other derived compounds except the oxime of the same compound, while 1,5-diphenylpenta-1,4-dien-3-one (in which the lengthening of the acyclic conjugated portion occurs) has almost no activity at 100 ppm at an interval of 24 h. ANOVA and CD values of the compounds show that larvicidal activity of 4-phenylbut-3-en-2-one and its oxime is greater than its phenylhydrazone, which has, however, higher activity than that of semicarbazone of 4-phenylbut-3-en-2- one. On the other hand the activities of 1,5-diphenylpenta-1,4-dien-3-one itself and 2,4-dinitrophenylhydrazone of chalcone and chalcone type compounds are almost nil at 100 ppm concentration at an interval of 24 h at 30 ± 2°C. The probable explanation of the fall of larvicidal activities of these compounds has been presented.