22924-19-2Relevant articles and documents
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease
Mezeiova, Eva,Janockova, Jana,Andrys, Rudolf,Soukup, Ondrej,Kobrlova, Tereza,Muckova, Lubica,Pejchal, Jaroslav,Simunkova, Miriama,Handl, Jiri,Micankova, Petra,Capek, Jan,Rousar, Tomas,Hrabinova, Martina,Nepovimova, Eugenie,Marco-Contelles, Jose Luis,Valko, Marian,Korabecny, Jan
, (2021)
Alzheimer's disease is a progressive brain disorder with characteristic symptoms and several pathological hallmarks. The concept of “one drug, one target” has not generated any new drugs since 2004. The new era of drug development in the field of AD build
Solar photochemistry: Optimisation of the photo Friedel-Crafts acylation of naphthoquinones
Mitchell, Lorna J.,Lewis, William,Moody, Christopher J.
supporting information, p. 2830 - 2842 (2013/10/08)
A practical and robust photo Friedel-Crafts acylation of naphthoquinones is described. Although the reaction proceeds slowly in sunlight, the optimised conditions offer a substantial improvement to those already reported, by the utilisation of a more reliable and practical 'sun-mimicking' light source, a less hazardous solvent system (trifluorotoluene) and faster reaction times. Using these conditions, the reaction scope has been expanded to include functionalised aldehyde and naphthoquinone substrates, affording the desired photo-products in acceptable to excellent yields (17-81%). Factors influencing the regiochemistry of the photo Friedel-Crafts reaction on unsymmetrical naphthoquinones have also been investigated.