22926-71-2

Basic information

• Product Name: Pyridine, 4-(5-phenyl-1,2,4-oxadiazol-3-yl)-
• CAS NO: 22926-71-2
• Molecular Formula: C13H9N3O
• Molecular Weight: 223.234
• Mol File: 22926-71-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-(5-phenyl-1,2,4-oxadiazol-3-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(5-phenyl-1,2,4-oxadiazol-3-yl)-(22926-71-2)
• EPA Substance Registry System: Pyridine, 4-(5-phenyl-1,2,4-oxadiazol-3-yl)-(22926-71-2)

Safety Data

• Hazardous Substances Data: 22926-71-2(Hazardous Substances Data)

Upstream product

• 1594-57-6 pyridine-4-carboxamidoxime 
• 100-52-7 benzaldehyde 
• 65-85-0 benzoic acid 
• 872-85-5 pyridine-4-carbaldehyde 
• 100-46-9 benzylamine 
• 93-89-0 benzoic acid ethyl ester 
• 100-48-1 pyridine-4-carbonitrile 
• 6345-27-3 4-amidinopyridine hydrochloride 
• 55-21-0 benzamide 
• 108-88-3 toluene 
• 1108606-15-0 C₁₃H₁₃N₃O 
• 696-54-8 pyridine-4-aldoxime 
• 1594-57-6 isonicotinamidoxime 

Relevant articles and documents

Synthesis and evaluation of 1,2,4-oxadiazole derivatives as potential anti-inflammatory agents by inhibiting NF-κB signaling pathway in LPS-stimulated RAW 264.7 cells

In this study, a series of compounds with 1,2,4-oxadiazole core was designed and synthesized for the optimization of JC01, an anti-inflammatory hit identified from our in-house compound library using NF-κB pathway luciferase assay and NO production assay.

Convenient one-pot synthesis of 1,2,4-oxadiazoles and 2,4,6-triarylpyridines using graphene oxide (GO) as a metal-free catalyst: Importance of dual catalytic activity

A convenient and efficient process for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles and 2,4,6-triarylpyridines has been described using an inexpensive, environmentally benign, metal-free heterogeneous carbocatalyst, graphene oxide (GO). GO plays a dual role of an oxidizing agent and solid acid catalyst for synthesizing 1,2,4-oxadiazoles and triarylpyridines. This dual catalytic activity of GO is due to the presence of oxygenated functional groups which are distributed on the nanosheets of graphene oxide. A broad scope of substrate applicability and good sustainability is offered in this developed protocol. The results of a few control experiments reveal a plausible mechanism and the role of GO as a catalyst was confirmed by FTIR, XRD, SEM, and HR-TEM analysis.

NBS-mediated practical cyclization of N-acyl amidines to 1,2,4-oxadiazoles via oxidative N?O bond formation

A reaction involving an efficient NBS-mediated oxidative N?O bond formation has been established for the synthesis of 1,2,4-oxadiazoles from readily accessible N-acyl amidines. The features of this synthetic method include simplicity of operation, mild re