22927-54-4

Basic information

• Product Name: 2?methyl?5?nitro?1?(prop?2?yn?1?yl)?1H?imidazole
• Synonyms: 2?methyl?5?nitro?1?(prop?2?yn?1?yl)?1H?imidazole
• CAS NO: 22927-54-4
• Molecular Weight: 165.151
• Mol File: 22927-54-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2?methyl?5?nitro?1?(prop?2?yn?1?yl)?1H?imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2?methyl?5?nitro?1?(prop?2?yn?1?yl)?1H?imidazole(22927-54-4)
• EPA Substance Registry System: 2?methyl?5?nitro?1?(prop?2?yn?1?yl)?1H?imidazole(22927-54-4)

Safety Data

• Hazardous Substances Data: 22927-54-4(Hazardous Substances Data)

Upstream product

• 696-23-1 2-methyl-5-nitro-1H-imidazole 
• 106-96-7 propargyl bromide 
• 6165-76-0 propargyl p-toluenesulfonate 

Relevant articles and documents

Silica-tethered cuprous acetophenone thiosemicarbazone (STCATSC) as a novel hybrid nano-catalyst for highly efficient synthesis of new 1,2,3-triazolyl-based metronidazole hybrid analogues having potent antigiardial activity

The preparation, characterization and application of silica-tethered cuprous acetophenone thiosemicarbazone (STCATSC) as a novel hybrid nano catalyst for synthesis of new 1,2,3-triazolyl-based metronidazole hybrid analogues is described. STCATSC is fully

A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers

Radiopharmaceuticals for nuclear imaging are essentially targeting molecules, labeled with short-lived radionuclides (e.g., F-18 for PET). A significant drawback of radiopharmaceuticals development is the difficulty to access radiolabeled molecule libraries for initial in vitro evaluation, as radiolabeling has to be optimized for each individual molecule. The present paper discloses a method for preparing libraries of 18F-labeled radiopharmaceuticals using both the fluorous-based 18F-radiochemistry and the Huisgen 1,3-dipolar (click) conjugation reaction. As a proof of concept, this approach allowed us to obtain a series of readily accessible 18F-radiolabeled nitroaromatic molecules, for exploring their structure-activity relationship and further in vitro evaluation of their hypoxic selectivity.