2293-61-0

Basic information

• Product Name: ethyl 3-hydroxy-3-phenylpentanoate
• Synonyms: Benzenepropanoic acid, .beta.-ethyl-.beta.-hydroxy-, ethyl ester
• CAS NO: 2293-61-0
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.2802
• Mol File: 2293-61-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 342.3°C at 760 mmHg
• Flash Point: 140.3°C
• Density: 1.075g/cm³
• Vapor Pressure: 2.93E-05mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: ethyl 3-hydroxy-3-phenylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-hydroxy-3-phenylpentanoate(2293-61-0)
• EPA Substance Registry System: ethyl 3-hydroxy-3-phenylpentanoate(2293-61-0)

Safety Data

• Hazardous Substances Data: 2293-61-0(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 93-55-0 1-phenyl-propan-1-one 
• 18295-66-4 1-ethoxy-1-(trimethylsiloxy)ethene 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 1528-59-2 ethyl (E)-3-phenylpent-2-enoate 
• 13278-26-7 3-hydroxy-3-phenylpentanoic acid 
• 21133-82-4 3-Ethyl-5-phenyl-heptane-3,5-diol 
• 21133-90-4 2-Methyl-4-phenyl-hexane-2,4-diol 
• 1528-58-1 (E)-3-phenyl-2-pentenoic acid 

Relevant articles and documents

Metal chloride-promoted aldol reaction of α-dimethylsilylesters with aldehydes, ketones, and α-enones

In the presence of a catalytic amount of LiCl, α-dimethylsilylesters (α-DMS-esters) 1 smoothly reacted with various aldehydes at 30°C to give aldols in good to high yields. On the other hand, the aldol reaction with ketones was effectively promoted by MgCl2 rather than by LiCl. α-Enones also underwent the metal chloride-promoted addition of 1 at the carbonyl carbon or β-carbon. Georg Thieme Verlag Stuttgart.

A new method for the catalytic aldol reaction to ketones

A new method for the catalytic aldol reaction to ketones, using CuF·3PPh3·2EtOH complex as the catalyst and (EtO)3SiF as the additive, is described. The reaction can be applied to a wide range of ketones and trimethylsilyl enolates. On the basis of mechanistic studies, a working hypothesis for the catalytic cycle is proposed, in which the dynamic ligand exchange mediated by copper silicates produces the active copper enolate. Moreover, the present reaction can be extended to the catalytic enantioselective reaction using tol-BINAP as a chiral ligand. Copyright

Microwave-promoted synthesis of β-hydroxyesters by the Reformatsky reaction in the absence of solvent

A microwave-promoted Reformatsky reaction of aldehydes and ketones with ethyl bromoacetate, in the absence of solvent, using activated zinc metal and solid NH4Cl afforded the corresponding β-hydroxyesters in good to excellent yields.