229307-62-4

Basic information

• Product Name: ethyl 7-((6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl)-oxy)-8-methyl-2-oxo-4-(phenylmethoxy)-2H-1-benzopyran-3-carboxylate
• Synonyms: ethyl 7-((6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl)-oxy)-8-methyl-2-oxo-4-(phenylmethoxy)-2H-1-benzopyran-3-carboxylate
• CAS NO: 229307-62-4
• Molecular Weight: 528.556
• Mol File: 229307-62-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 7-((6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl)-oxy)-8-methyl-2-oxo-4-(phenylmethoxy)-2H-1-benzopyran-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 7-((6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl)-oxy)-8-methyl-2-oxo-4-(phenylmethoxy)-2H-1-benzopyran-3-carboxylate(229307-62-4)
• EPA Substance Registry System: ethyl 7-((6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl)-oxy)-8-methyl-2-oxo-4-(phenylmethoxy)-2H-1-benzopyran-3-carboxylate(229307-62-4)

Safety Data

• Hazardous Substances Data: 229307-62-4(Hazardous Substances Data)

Upstream product

• 470-31-5 α-L-(+)-noviose 
• 200729-01-7 ethyl 7-hydroxy 8-methyl-2-oxo-4-(phenyl-methoxy)-2H-1-benzopyran-3-carboxylate 
• 200726-79-0 4-hydroxy-8-methyl-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-2-one 
• 107739-83-3 (+)-6-deoxy-5-C,4-O-dimethyl-L-xylo-hexopyranose 
• 200726-99-4 ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate 
• 200727-00-0 ethyl 4-hydroxy-8-methyl-2-oxo-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate 

Downstream Products

• 229307-63-5 4-Benzyloxy-7-((2R,3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromene-3-carboxylic acid ethyl ester 

Relevant articles and documents

Aromatic derivatives substituted by a ribose, their method of preparation and application as medicine

A subject of the invention is the compounds of formula (I): R1=H, OH, alkyl, alkenyl or alkynyl optionally substituted or alkoxy, R2=H, Hal, R3=H, alkyl, Hal, Rg and Rh: H, alkyl, aryl heterocycle, R5=H or O-alkyl, R6=alkyl or CH2—O-alkyl, R7=H or alkyl. The compounds of formula (I) have antibiotic properties.

Coumarin inhibitors of gyrase B with N-propargyloxy-carbamate as an effective pyrrole bioisostere

The synthesis and biological profile in vitro of a series of coumarin inhibitors of gyrase B bearing a N-propargyloxycarbamate at C-3' of noviose is presented. Replacement of the 5-methylpyrrole-2-carboxylate of coumarin drugs with an N-propargyloxycarbamate bioisostere leads to analogues with improved antibacterial activity. Analysis of crystal structures of coumarin antibiotics with the 24 kDa N-terminal domain of the gyrase B protein provides a rational for the excellent inhibitory potency of C-3' N- alkoxycarbamates.