22934-47-0

Basic information

• Product Name: 1-(3-ethyl-4-hydroxyphenyl)ethanone
• Synonyms: 1-(3-ethyl-4-hydroxyphenyl)ethanone
• CAS NO: 22934-47-0
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• Mol File: 22934-47-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 95°C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-ethyl-4-hydroxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-ethyl-4-hydroxyphenyl)ethanone(22934-47-0)
• EPA Substance Registry System: 1-(3-ethyl-4-hydroxyphenyl)ethanone(22934-47-0)

Safety Data

• Hazardous Substances Data: 22934-47-0(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of acetyl chloride on 2-ethylphenol with aluminium chloride, ? in refluxing carbon disulfide (60%) ; ? in nitrobenzene at 60° (39%).

Upstream product

• 90-00-6 o-Hydroxyethylbenzene 
• 3056-59-5 acetate d'ethyl-2 phenyl 
• 75-36-5 acetyl chloride 
• 97-94-9 triethyl borane 
• 1836-06-2 3-bromo-4-hydroxyacetophenone 

Downstream Products

• 101276-86-2 1-(3-ethyl-4-cyclohexyloxy-phenyl)-ethanone 
• 29643-35-4 1-(4-Ethoxy-3-ethyl-phenyl)-ethanone 
• 29643-45-6 1-(3-Ethyl-4-isobutoxy-phenyl)-ethanone 
• 29643-38-7 1-(3-Ethyl-4-pentyloxy-phenyl)-ethanone 
• 29643-39-8 1-(3-Ethyl-4-hexyloxy-phenyl)-ethanone 
• 29643-43-4 1-(4-Decyloxy-3-ethyl-phenyl)-ethanone 
• 29643-34-3 1-(3-ethyl-4-methoxyphenyl)ethan-1-one 
• 29643-46-7 1-[3-Ethyl-4-(3-methyl-butoxy)-phenyl]-ethanone 
• 73898-24-5 2-bromo-(3-ethyl-4-hydroxyphenyl)ethanone 
• 95763-98-7 2-Aethyl-4-methoxycarbonyl-cyclohexanol 

Relevant articles and documents

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists

Free fatty acid receptor 1 (FFA1) is a new potential drug target for the treatment of type 2 diabetes because of its role in amplifying glucose-stimulated insulin secretion in pancreatic β-cell. In the present studies, we identified phenoxyacetic acid derivative (18b) as a potent FFA1 agonist (EC50 = 62.3 nM) based on the structure of phenylpropanoic acid derivative 4p. Moreover, compound 18b could significantly improve oral glucose tolerance in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice without observation of hypoglycemic side effect. Additionally, compound 18b exhibited acceptable PK profiles. In summary, compound 18b with ideal PK profiles exhibited good activity in vitro and in vivo, and might be a promising drug candidate for the treatment of diabetes mellitus.

B-Alkyl Suzuki-Miyaura cross-coupling of tri-n-alkylboranes with arylbromides bearing acidic functions under mild non-aqueous conditions

An efficient and chemoselective Pd-catalyzed B-alkyl Suzuki-Miyaura cross-coupling of tri-n-alkylboranes with arylbromides possessing acidic functions is described. This protocol features the relatively weak base Cs2CO3 and mild non-

4-alkoxy-3-ethylacetophenone

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