229496-33-7

Basic information

• Product Name: Carbamic acid, [2-(2-bromophenyl)ethyl]-, phenylmethyl ester
• CAS NO: 229496-33-7
• Molecular Formula: C16H16BrNO2
• Molecular Weight: 334.213
• Mol File: 229496-33-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-(2-bromophenyl)ethyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-(2-bromophenyl)ethyl]-, phenylmethyl ester(229496-33-7)
• EPA Substance Registry System: Carbamic acid, [2-(2-bromophenyl)ethyl]-, phenylmethyl ester(229496-33-7)

Safety Data

• Hazardous Substances Data: 229496-33-7(Hazardous Substances Data)

Upstream product

• 65185-58-2 2-(2-bromophenyl)ethanamine 
• 501-53-1 benzyl chloroformate 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 

Downstream Products

• 1273546-95-4 (3S)-(E)-N-Cbz-N-[2-[2-(3-tert-butyldimethylsilyloxy-1-butenyl)phenyl]ethyl]amine 
• 1273547-06-0 (3S)-(E)-N-Cbz-N-[2-[2-(3-hydroxy-1-butenyl)phenyl]ethyl]amine 
• 1307795-03-4 N-(2-{4'-[(1R,3'S)-5-fluoro-6-methoxy-3-oxo-3H-spiro[2-benzofuran-1,4'-piperidin]-3'-yl]-3'-methyl-2-biphenylyl}ethyl)-2-hydroxyacetamide 
• 1307795-94-3 tert-butyl (1R,3'S)-5-fluoro-3'-{2'-[2-(glycoloylamino)ethyl]-3-methyl-4-biphenylyl}-6-methoxy-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1307795-01-2 N-(2-{4'-[(1R,3'S)-5,6-difluoro-3-oxo-3H-spiro[2-benzofuran-1,4'-piperidin]-3'-yl]-3'-methyl-2-biphenylyl}ethyl)-2-hydroxyacetamide 
• 1307795-92-1 tert-butyl (1R,3'S)-5,6-difluoro-3'-{2'-[2-(glycoloylamino)ethyl]-3-methyl-4-biphenylyl}-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1307795-91-0 tert-butyl (1R,3'S)-3'-[2'-(2-{[(acetyloxy)acetyl]amino}ethyl)-3-methyl-4-biphenylyl]-5,6-difluoro-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1307794-99-5 methyl (2-{4'-[(1R,3'S)-5,6-difluoro-3-oxo-3H-spiro[2-benzofuran-1,4'-piperidin]-3'-yl]-3'-methyl-2-biphenylyl}ethyl)carbamate hydrochloride 
• 1307795-89-6 tert-butyl (1R,3'S)-5,6-difluoro-3'-(2'-{2-[(methoxycarbonyl)amino]ethyl}-3-methyl-4-biphenylyl)-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1307795-88-5 tert-butyl (1R,3'S)-5,6-difluoro-3'-{3-methyl-2'-[2-(propionylamino)ethyl]-4-biphenylyl}-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1307794-95-1 N-(2-{4'-[(1R,3'S)-5,6-difluoro-3-oxo-3H-spiro(2-benzofuran-1,4'-piperidin)-3'-yl]-3'-methyl-2-biphenylyl}ethyl)acetamide hydrochloride 
• 1307795-85-2 tert-butyl (1R,3'S)-3'-{2'-[2-(acetylamino)ethyl]-3-methyl-4-biphenylyl}-5,6-difluoro-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1307795-83-0 tert-butyl (1R,3'S)-3'-[2'-(2-aminoethyl)-3-methyl-4-biphenylyl]-5,6-difluoro-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1307795-80-7 tert-butyl (1R,3'S)-3'-[2'-(2-{[(benzyloxy)carbonyl]amino}ethyl)-3-methyl-4-biphenylyl]-5,6-difluoro-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 

Relevant articles and documents

Preparation method of (S)-5-bromo-1, 2, 3, 4-tetrahydro-N-Boc-isoquinoline-1-carboxylic acid

The invention discloses a preparation method for synthesizing (S)-5-bromo-1, 2, 3, 4-tetrahydro-N-Boc-isoquinoline-1-carboxylic acid, and belongs to the technical field of medical intermediates. The method comprises the following steps: reacting o-bromophenylethylamine serving as a raw material with benzyl chloroformate in an alkaline environment to obtain benzyl o-bromophenylethylamine formate; then carrying out cyclization reaction with glyoxylic acid under the catalysis of acid; then carrying out palladium-carbon catalytic hydrogenation to remove protection, so as to obtain 5-bromo-1, 2, 3, 4-tetrahydroisoquinoline-1-carboxylic acid; finally, obtaining the (S)-5-bromo-1, 2, 3, 4-tetrahydro-N-Boc-isoquinoline-1-carboxylic acid through induced resolution and Boc protection. The method is simple, convenient and stable in process operation, high in yield, environmentally friendly, cheap and easily available in raw materials and beneficial to industrial production.

A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc

A unique combination of CuI and CsOAc was found to catalyze aryl amination under mild conditions. The reaction takes place at room temperature or at 90 °C with broad functional group compatibility. The intramolecular reaction was able to form five-, six-, and seven-membered rings with various protecting groups on the nitrogen atom. The scope of the intermolecular amination, as well as its applications to unsymmetrical N,N′-dialkylated phenylenediamines, was investigated.