229647-15-8

Basic information

• Product Name: 2-Piperazinecarboxylic acid, 4-[(6-chloro-2-naphthalenyl)sulfonyl]-1-(phenylmethyl)-, ethyl ester
• CAS NO: 229647-15-8
• Molecular Formula: C24H25ClN2O4S
• Molecular Weight: 472.993
• Mol File: 229647-15-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Piperazinecarboxylic acid, 4-[(6-chloro-2-naphthalenyl)sulfonyl]-1-(phenylmethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperazinecarboxylic acid, 4-[(6-chloro-2-naphthalenyl)sulfonyl]-1-(phenylmethyl)-, ethyl ester(229647-15-8)
• EPA Substance Registry System: 2-Piperazinecarboxylic acid, 4-[(6-chloro-2-naphthalenyl)sulfonyl]-1-(phenylmethyl)-, ethyl ester(229647-15-8)

Safety Data

• Hazardous Substances Data: 229647-15-8(Hazardous Substances Data)

Upstream product

• 102153-63-9 6-chloronaphth-2-ylsulfonyl chloride 
• 134749-45-4 ethyl 1-benzylpiperazine-2-carboxylate 

Relevant articles and documents

Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitor

Intravascular clot formation is an important factor in a number of cardiovascular diseases. Therefore, the prevention of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (FXa), which is a key enzyme in coagulation cascade responsible for the generation of thrombin by limited proteolysis of its zymogen, prothrombin. We have investigated 1-arylsulfonyl-3-piperazinone derivatives, containing a 4-(piperidino)pyridine group in place of guanidino and/or amidino groups, and discovered compound M55113 (30a: 4-[(6-Chloro-2-naphthalenyl)sulfonyl]-1-[[1-(4-pyridinyl)-4-piperidinyl]- methyl]piperazinone), as a potent inhibitor of FXa (IC50=0.06 μM) with high selectivity for FXa over trypsin and thrombin.