22975-58-2

Basic information

• Product Name: 1-(1-ETHYL-PROPYL)-4-METHYL-BENZENE
• Synonyms: 1-(1-ETHYL-PROPYL)-4-METHYL-BENZENE;1-Methyl-4-(pentane-3-yl)benzene;3-(p-Tolyl)pentane
• CAS NO: 22975-58-2
• Molecular Formula: C₁₂H₁₈
• Molecular Weight: 162.27132
• Mol File: 22975-58-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 216.8°Cat760mmHg
• Flash Point: 79.2°C
• Appearance: /
• Density: 0.859g/cm³
• Vapor Pressure: 0.201mmHg at 25°C
• Refractive Index: 1.489
• CAS DataBase Reference: 1-(1-ETHYL-PROPYL)-4-METHYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-ETHYL-PROPYL)-4-METHYL-BENZENE(22975-58-2)
• EPA Substance Registry System: 1-(1-ETHYL-PROPYL)-4-METHYL-BENZENE(22975-58-2)

Safety Data

• Hazardous Substances Data: 22975-58-2(Hazardous Substances Data)

Usage

Description

1-(1-Ethyl-propyl)-4-methyl-benzene, also known as 1-ethyl-4-isopropyltoluene, is a chemical compound with the molecular formula C12H18. It is a colorless liquid with a faint odor and is known for its aromatic and solvent properties, making it a versatile compound in various industries.

Uses

Used in Fragrance Industry:
1-(1-Ethyl-propyl)-4-methyl-benzene is used as a fragrance ingredient for its aromatic properties, adding pleasant scents to perfumes and personal care products.
Used in Industrial Applications:
In the industrial sector, 1-(1-ethyl-propyl)-4-methyl-benzene is used as a solvent, facilitating various chemical processes and reactions.
Used in Chemical Manufacturing:
1-(1-ETHYL-PROPYL)-4-METHYL-BENZENE is also utilized in the production of other chemicals, contributing to the synthesis of a wide range of products.
It is important to handle and store 1-(1-ethyl-propyl)-4-methyl-benzene with caution, as it can be harmful if it comes into contact with the skin, eyes, or if it is inhaled. Overall, due to its aromatic and solvent properties, 1-(1-ethyl-propyl)-4-methyl-benzene plays a significant role in the fragrance, industrial, and chemical manufacturing industries.

InChI:InChI=1/C12H18/c1-4-11(5-2)12-8-6-10(3)7-9-12/h6-9,11H,4-5H2,1-3H3

Upstream product

• 74-85-1 ethene 
• 106-42-3 para-xylene 
• 96-22-0 pentan-3-one 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 1809-10-5 3-bromopentane 
• 108-88-3 toluene 
• 106-38-7 para-bromotoluene 
• 23229-29-0 2-(4-methylphenyl)-1,3-dithiolane 
• 925-90-6 ethylmagnesium bromide 
• 6032-29-7 (+/-)-2-pentanol 
• 584-02-1 2-pentanol 
• 120-12-7 anthracene 
• 110-53-2 1-Bromopentane 
• 29540-83-8 p-tolyl triflate 

Downstream Products

• 23020-24-8 cis-1-Methyl-4-(1-aethylpropyl)cyclohexan 

Relevant articles and documents

Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling

Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada-Tamao-Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp2-hybridized electrophiles as well as aryl Grignard reagents with sp3-hybridized electrophiles. This represents a rare example of a single iron-catalyzed system effective across diverse coupling reactions without significant modification of the catalytic protocol, as well as remaining operationally simple.

Microwave-assisted silica-supported aluminum chloride-catalyzed Friedel-Crafts alkylation

Microwave irradiation is a popular method in organic synthesis to achieve high yields in shorter reaction times. This decreases total 'man-hours' in a synthetic setting. Another technique used in organic chemistry to decrease manual manipulations, is solid support reagents. The benefits of this approach is that upon completion of a reaction, a simple filtration can be performed which expedites the work-up and also produces less organic waste. Friedel-Crafts alkylation has been explored using microwave chemistry as well as with solid-supported reagents. In comparison with traditional heating, as well as with AlCl3, superior yields were observed with silica-gel bound aluminum chloride (Si-AlClx) when microwave irradiated for only 5 min.

Iron(III) amine-bis(phenolate) complexes as catalysts for the coupling of alkyl halides with aryl Grignard reagents

Catalytic cross-coupling of aryl Grignard reagents with primary and secondary alkyl halides bearing β-hydrogens is achieved using Fe(III) amine-bis(phenolate) halide complexes. The Royal Society of Chemistry.