22976-40-5

Basic information

• Product Name: Olivetol Dimethyl Ether
• Synonyms: Olivetol Dimethyl Ether;1,3-DiMethoxy-5-pentylbenzene;1,3-DiMethoxy-5-pentyl-benzene;3,5-DiMethoxyaMylbenzene;5-Pentylresorcinol DiMethyl Ether;Di-O-Methylolivetol
• CAS NO: 22976-40-5
• Molecular Formula: C₁₃H₂₀O₂
• Molecular Weight: 208.2967
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 22976-40-5.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 130 °C
• Appearance: /
• Density: 0.978 g/cm3(Temp: 25 °C)
• Solubility: Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: Olivetol Dimethyl Ether(CAS DataBase Reference)
• NIST Chemistry Reference: Olivetol Dimethyl Ether(22976-40-5)
• EPA Substance Registry System: Olivetol Dimethyl Ether(22976-40-5)

Safety Data

• Hazardous Substances Data: 22976-40-5(Hazardous Substances Data)

Usage

Description

Olivetol Dimethyl Ether is an off-white solid that serves as an intermediate in various syntheses of tetrahydrocannabinol (THC), a compound found in the cannabis plant.

Uses

Used in Pharmaceutical Industry:
Olivetol Dimethyl Ether is used as an intermediate for the synthesis of tetrahydrocannabinol (THC) due to its role in the production process of this compound. This application is significant in the development of medications and therapies that utilize the properties of THC for various medical conditions.

Synthesis Reference(s)

Tetrahedron Letters, 17, p. 2079, 1976 DOI: 10.1016/S0040-4039(00)93823-1

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 71-43-2 benzene 
• 34814-28-3 2-(3,5-dimethoxy-benzyl)-thiophene 
• 41497-39-6 1-(3,5-Dimethoxyphenyl)-2-methylsulfonyl-pentan-3-on 
• 110-53-2 1-Bromopentane 
• 52189-63-6 3,5-dimethoxyfluorobenzene 
• 628-17-1 amyl iodide 
• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 38228-28-3 1-(1-hydroxypentyl)-3,5-dimethoxybenzene 
• 5366-07-4 planaic acid 
• 114085-79-9 1-n-pentyl-3,4,5-trimethoxybenzene 
• 79987-63-6 2-iodo-1,5-dimethoxy-3-pentylbenzene 
• 77-78-1 dimethyl sulfate 
• 500-66-3 Olivetol 

Downstream Products

• 15121-94-5 primine 
• 3410-84-2 2,6-dimethoxy-4-pentylbenzaldehyde 
• 112639-04-0 2,4-dibromo-1,5-dimethoxy-3-pentylbenzene 
• 500-66-3 Olivetol 
• 1242-67-7 O-2797 
• 83036-53-7 1,3-Dimethoxy-2-(3-methyl-but-2-enyl)-5-pentyl-benzene 
• 83036-54-8 1,5-Dimethoxy-2-(3-methyl-but-2-enyl)-3-pentyl-benzene 
• 29106-16-9 1,3-bis(methoxy)cannabigerol 
• 83036-55-9 2-((E)-3,7-Dimethyl-octa-2,6-dienyl)-1,5-dimethoxy-3-pentyl-benzene 
• 41408-15-5 olivetol monomethyl ether 
• 112639-01-7 2-bromo-1,5-dimethoxy-3-pentyl-benzene 
• 89244-01-9 2,4- Dimethoxy-6-pentylphenol 
• 79987-70-5 2,4-diiodo-1,5-dimethoxy-3-pentylbenzene 
• 79987-63-6 2-iodo-1,5-dimethoxy-3-pentylbenzene 

Relevant articles and documents

On the deprotonation of η6-1,3-dimethoxybenzene-Cr(CO)3 derivatives: Influence of the reaction conditions on the regioselectivity

The regioselectivity of deprotonation/alkylation reactions of η6-1,3-dimethoxybenzene-Cr(CO)3 (5), η6-1,3-dimethoxy-5-methylbenzene-Cr(CO)3 (6) and 2-substituted derivatives of these compounds was investigated.

CANNABINOID DERIVATIVES

This disclosure relates to cannabinoid derivatives of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in treating or preventing a diseases associated with a cannabinoid receptor in a subject in ne

Preparation method of 3,5-dihydroxyamylbenzene

The invention provides a preparation method of 3,5-dihydroxyamylbenzene. The preparation method comprises the following steps: with a 3,5-dialkoxy benzoate compound as a raw material, subjecting the 3,5-dialkoxy benzoate compound to reacting with valeronitrile to generate a beta-ketone nitrile compound, hydrolyzing a cyano group to generate a carboxylic acid compound, performing a decarboxylation reaction to obtain 3,5-dialkoxyphenylpentanone, performing Huang Ming-long reaction or catalytic hydrogenation to convert 3,5-dialkoxyphenylpentanone into 3,5-dialkoxyamylbenzene, and finally, reducing an alkoxy group into a phenolic hydroxyl group so as to obtain 3,5-dihydroxyamylbenzene. The preparation method provided by the invention overcomes the defects of high cost, complex route, low yield, poor purity and the like of traditional processes.

Synthesis method of 3, 5-dihydroxypentene benzene

The invention provides a synthesis method of 3, 5-dihydroxypentene benzene. The synthesis method comprises the following steps: reacting 3, 5-dimethoxyphenol used as a raw material with a sulfonate halide reagent to generate sulfonate, carrying out cross-coupling reaction with a nucleophilic reagent to introduce amyl, and finally reducing methoxyl into phenolic hydroxyl, thereby obtaining the product 3, 5-dihydroxypentene benzene. The synthesis method solves the defects of high cost, complex route, low yield, poor purity and the like of the traditional process.