22984-72-1

Basic information

• Product Name: 2-cyano-4-oxo-4-phenyl-butyric acid
• Synonyms: 2-cyano-4-oxo-4-phenyl-butyric acid
• CAS NO: 22984-72-1
• Molecular Weight: 203.197
• Mol File: 22984-72-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-cyano-4-oxo-4-phenyl-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-4-oxo-4-phenyl-butyric acid(22984-72-1)
• EPA Substance Registry System: 2-cyano-4-oxo-4-phenyl-butyric acid(22984-72-1)

Safety Data

• Hazardous Substances Data: 22984-72-1(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 5343-98-6 4-oxo-4-phenylbutanenitrile 
• 70-11-1 α-bromoacetophenone 
• 22984-74-3 Ethyl 2-cyano-4-oxo-4-phenylbutanoate 
• 7732-18-5 water 
• 583-06-2 3-benzoylacrylic acid 
• 151-50-8 potassium cyanide 

Downstream Products

• 6005-95-4 acide tetrahydro-2-oxo-5-phenylfurane-3-carboxylique 
• 3042-22-6 2-phenyl-1H-pyrrole 
• 5538-01-2 phenacyl-malonic acid 
• 2051-95-8 succinylbenzene 
• 33574-07-1 tetrahydro-2-oxo-5-phenyl-3-furancarbonitrile 
• 101575-80-8 2-(1-methyl-[4]piperidyl)-3-oxo-6-phenyl-2,3-dihydro-pyridazine-4-carbonitrile 

Relevant articles and documents

Regiospecific decarboxylative allylation of nitriles

[Chemical Equation Presented] Palladium-catalyzed decarboxylative α-allylation of nitriles readily occurs with use of Pd2(dba) 3 and rac-BINAP. This catalyst mixture also allows the highly regiospecific α-allylation of nitriles in the presence of much more acidic α-protons. Thus, the reported method provides access to compounds that are not readily available via base-mediated allylation chemistries. Lastly, mechanistic investigations indicate that there is a competition between C- and N-allylation of an intermediate nitrile-stabilized anion and that N-allylation is followed by a rapid [3,3]-sigmatropic rearrangement.