229949-53-5Relevant articles and documents
Synthesis and antinociceptive activity of orally active opioid peptides: Improvement of oral bioavailability by esterification
Ogawa, Tadashi,Araki, Mamoru,Miyamae, Tetsuhisa,Okayama, Toru,Hagiwara, Masaki,Sakurada, Shinobu,Morikawa, Tadanori
, p. 759 - 771 (2007/10/03)
To improve the oral bioavailability of a dermorphin tetrapeptide analog, Nα-1-iminoethyl-Tyr-D-MetO-Phe-MeβAla-OH (III), 1) which has a potent analgesic activity after oral administration, various derivatives were synthesized to incr