229957-07-7

Basic information

• Product Name: 3,4-DIFLUOROBENZOIC ACID HYDRAZIDE
• Synonyms: 3,4-DIFLUOROBENZENE-1-CARBOHYDRAZIDE;3,4-DIFLUOROBENZHYDRAZIDE;3,4-DIFLUOROBENZOIC ACID HYDRAZIDE;3,4-DIFLUOROBENZOIC HYDRAZIDE
• CAS NO: 229957-07-7
• Molecular Formula: C₇H₆F₂N₂O
• Molecular Weight: 172.13
• Product Categories: Fluorine Compounds
• Mol File: 229957-07-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 143-145°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.372g/cm³
• Refractive Index: 1.53
• CAS DataBase Reference: 3,4-DIFLUOROBENZOIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIFLUOROBENZOIC ACID HYDRAZIDE(229957-07-7)
• EPA Substance Registry System: 3,4-DIFLUOROBENZOIC ACID HYDRAZIDE(229957-07-7)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• Hazardous Substances Data: 229957-07-7(Hazardous Substances Data)

Usage

General Description

3,4-Difluorobenzoic acid hydrazide is a chemical compound with the molecular formula C7H5F2N2O2. It is a white solid that is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 3,4-DIFLUOROBENZOIC ACID HYDRAZIDE is a derivative of benzoic acid and contains two fluorine atoms at the 3 and 4 positions on the benzene ring. It is a hydrazide, meaning it contains a functional group with a nitrogen atom linked to a carbonyl group. 3,4-Difluorobenzoic acid hydrazide is an important building block in organic synthesis for the preparation of various compounds with potential biological activities.

InChI:InChI=1/C7H6F2N2O/c8-5-2-1-4(3-6(5)9)7(12)11-10/h1-3H,10H2,(H,11,12)

Upstream product

• 369-25-5 methyl 3,4-difluorobenzoate 
• 455-86-7 3,4-Difluorobenzoic acid 
• 76903-88-3 3,4-difluorobenzoyl chloride 

Downstream Products

• 1021939-00-3 4-[N'-(3,4-difluorobenzoyl)hydrazino]-4-oxobutyric acid ethyl ester 
• 1182368-02-0 N'-((2R,3R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoyl)-3,4-difluorobenzohydrazide 
• 1093391-00-4 C₈H₄F₂N₂OS 
• 1016715-11-9 C₈H₆F₂N₄ 
• 1456614-11-1 C₁₂H₁₁F₂N₅O₂S 
• 1456613-89-0 2-(3,4-difluorophenyl)-5-thioxo-5,6-dihydro-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one 
• 1445207-05-5 2-bromo-5-(5-(3,4-difluorophenyl)-4H-1,2,4-triazol-3-yl)pyridine 
• 1445205-21-9 2-butoxy-5-(5-(5-(3,4-difluorophenyl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)pyrimidine 

Relevant articles and documents

AMINO ALCOHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present invention also discloses a pharmaceutical composition comprising the above substances, and a use of the substance in the preparation of a medicament for the prevention and treatment of an immune inflammatory disease, or a disease or condition associated with immunological competence such as multiple sclerosis, ALS, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis, polymyositis, etc.

Inhibition of tobacco bacterial wilt with sulfone derivatives containing an 1,3,4-oxadiazole moiety

A series of new sulfone compounds containing the 1,3,4-oxadiazole moiety were designed and synthesized. Their structures were identified by 1H and 13C nuclear magnetic resonance and elemental analyses. Antibacterial bioassays indicated that most compounds exhibited promising in vitro antibacterial bioactivities against tobacco bacterial wilt at 200 μg/mL. The relationship between structure and antibacterial activity was also discussed. Among the title compounds, 5′c, 5′h, 5′i, and 5′j could inhibit mycelia growth of Ralstonia solanacearum in vitro by approximately 50% (EC50) at 39.8, 60.3, 47.9, and 32.1 μg/mL, respectively. Among them, compound 5′j was identified as the most promising candidate due to its stronger effect than that of Kocide 3000 [Cu(OH)2] within the same concentration range. Field trials demonstrated that the control effect of compound 5′j against tobacco bacterial wilt was better than that of the commercial bactericide Saisentong. For the first time, the present work demonstrated that sulfone derivatives containing 1,3,4-oxadiazole can be used to develop potential bactericides for plants.