229961-45-9

Basic information

• Product Name: AGN 194310
• Synonyms: AGN 194310
• CAS NO: 229961-45-9
• Molecular Formula: C28H24O2S
• Molecular Weight: 424.55396
• Mol File: 229961-45-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AGN 194310(CAS DataBase Reference)
• NIST Chemistry Reference: AGN 194310(229961-45-9)
• EPA Substance Registry System: AGN 194310(229961-45-9)

Safety Data

• Hazardous Substances Data: 229961-45-9(Hazardous Substances Data)

Usage

General Description

AGN 194310 is a chemical compound that acts as an investigational drug with potential applications in the treatment of various medical conditions. It is a small molecule inhibitor of the non-receptor tyrosine kinase c-src, which plays a key role in cell signaling and regulation of cell growth and differentiation. AGN 194310 has shown promise in preclinical studies for the treatment of certain cancers, including breast and colon cancer, as well as potential applications in the treatment of inflammatory and autoimmune diseases. Its mechanism of action involves the inhibition of c-src, which can disrupt signaling pathways that promote cancer cell proliferation and survival, as well as inflammation. AGN 194310 is currently undergoing further evaluation in clinical trials to assess its safety and efficacy in humans.

Upstream product

• 229961-27-7 ethyl 4-<<4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl>ethynyl>-benzoate 
• 696-63-9 4-Methoxybenzenethiol 
• 541-47-9 3-Methylbutenoic acid 
• 111424-51-2 6-methoxy-2,2-dimethyl-thiochroman-4-one 
• 111424-46-5 3-(4-methoxy-phenylsulfanyl)-3-methyl-butyric acid 
• 229961-88-0 6-hydroxy-2,2-dimethyl-thiochroman-4-one 
• 229961-87-9 3-(4-methoxy-phenylsulfanyl)-3-methyl-butyric acid chloride 
• 229961-91-5 6-ethynyl-2,2,-dimethylthiochroman-4-one 
• 229961-90-4 2,2-dimethyl-6-trimethylsilanyl-ethynyl-thiochroman-4-one 
• 229961-89-1 2,2-dimethyl-4-oxo-thiochroman-6-yl trifluoromethanesulfonate 
• 229961-22-2 ethyl 4-<(2,2-dimethyl-4-oxo-thiochroman-6-yl)ethynyl>benzoate 
• 229961-23-3 ethyl 4-((2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-yl)ethynyl)-benzoate 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 155105-68-3 4-(4-ethylphenyl)-2-methylbut-3-yn-2-ol 

Relevant articles and documents

From Propargylic Alcohols to Substituted Thiochromenes: Gem-Disubstituent Effect in Intramolecular Alkyne Iodo/hydroarylation

This work describes the 6-endo-dig cyclization of S-aryl propargyl sulfides to afford 2H-thiochromenes. The substitution at the propargylic position plays a crucial role in allowing intramolecular silver-catalyzed alkyne hydroarylation and N-iodosuccinimide-promoted iodoarylation. Additionally, a PTSA-catalyzed thiolation reaction of propargylic alcohols was developed to synthesize the required tertiary S-aryl propargyl ethers. The applicability of merging these two methods is demonstrated by synthesizing the retinoic acid receptor antagonist AGN194310.

Methods of treatment during vascular procedures

The invention provides in one embodiment a method for treating vascular trauma. The method can include administering to an individual undergoing vascular trauma an effective amount of a retinoic acid receptor (RAR) antagonist or an RAR inhibitor. The meth

Synthesis and biological activity of high-affinity retinoic acid receptor antagonists

This article reports the synthesis and biological activity of new high affinity retinioic acid receptor (RAR) antagonists. The effect of introducing heteroatoms in the bicyclic ring system of the potent dihydronaphthalene RAR antagonist 8, and the variation of the pendant aromatic group on the ability of these compounds to function as RAR antagonists is discussed. The use of binding, transcriptional, and in vivo assays revealed that the 2,2-dimethylthiochromene analogue 59, and the 2,2-dimethylchromene derivative 85, were the most effective in blocking retinoid agonist induced activity. Copyright (C) 1999 Elsevier Science Ltd.