2300-03-0 Usage
General Description
6α-Fluoropregn-4-ene-3,20-dione is a synthetic steroid hormone and a derivative of progesterone. It is a potent anti-inflammatory, anti-allergic, and immunosuppressive agent. This chemical compound has been used in the development of various pharmaceuticals, including corticosteroids such as flumethasone and halopredone acetate, which are used for their anti-inflammatory and immunosuppressive properties. The fluorine atom at the 6α position of the molecule increases its potency and duration of action. 6α-Fluoropregn-4-ene-3,20-dione has potential applications in the treatment of various inflammatory and allergic conditions, as well as in the development of new pharmaceuticals for these purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 2300-03-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,0 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2300-03:
(6*2)+(5*3)+(4*0)+(3*0)+(2*0)+(1*3)=30
30 % 10 = 0
So 2300-03-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H29FO2/c1-12(23)15-4-5-16-14-11-19(22)18-10-13(24)6-8-21(18,3)17(14)7-9-20(15,16)2/h10,14-17,19H,4-9,11H2,1-3H3/t14-,15+,16-,17-,19-,20+,21+/m0/s1
2300-03-0Relevant articles and documents
Kinetics of Electrophilic Fluorination of Steroids and Epimerisation of Fluorosteroids
Rozatian, Neshat,Harsanyi, Antal,Murray, Ben J.,Hampton, Alexander S.,Chin, Emily J.,Cook, Alexander S.,Hodgson, David R. W.,Sandford, Graham
, p. 12027 - 12035 (2020/08/28)
Fluorinated steroids, which are synthesised by electrophilic fluorination, form a significant proportion of marketed pharmaceuticals. To gain quantitative information on fluorination at the 6-position of steroids, kinetics studies were conducted on enol ester derivatives of progesterone, testosterone, cholestenone and hydrocortisone with a series of electrophilic N?F reagents. The stereoselectivities of fluorination reactions of progesterone enol acetate and the kinetic effects of additives, including methanol and water, were investigated. The kinetics of epimerisation of 6β-fluoroprogesterone to the more pharmacologically active 6α-fluoroprogesterone isomer in HCl/acetic acid solutions are detailed.
