23000-31-9

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 6-methyl-3-phenyl-
• CAS NO: 23000-31-9
• Molecular Formula: C16H12O2
• Molecular Weight: 236.27
• Mol File: 23000-31-9.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 6-methyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 6-methyl-3-phenyl-(23000-31-9)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 6-methyl-3-phenyl-(23000-31-9)

Safety Data

• Hazardous Substances Data: 23000-31-9(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 103-80-0 phenylacetyl chloride 
• 92-48-8 6-methylcoumarin 
• 71-43-2 benzene 
• 59-88-1 phenylhydrazine hydrochloride 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 100-44-7 benzyl chloride 
• 62-53-3 aniline 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 1333483-14-9 N-methyll-N-(phenylethylnyl)methanesulfonamide 
• 536-74-3 phenylacetylene 
• 100-63-0 phenylhydrazine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1253967-62-2 6-bromomethyl-3-phenylcoumarin 
• 1404302-04-0 (S)-6-methyl-3-phenylspiro[chroman-2,2'-[1,3]dithiane] 
• 1404301-63-8 6-methyl-3-phenylhydrocoumarin 
• 1387531-03-4 6-formyl-3-phenylcoumarin 

Relevant articles and documents

Chlorophyll-catalyzed photochemical regioselective coumarin C-H arylation with diazonium salts

This communication describes the development of a mild method for the cross-coupling of the C3-position of coumarin with an array of diazonium salts mediated by chlorophyll as a biocatalyst via visible light catalysis. A natural pigment such as chlorophyll is used as a green photosensitizer and environmentally benign catalyst. This general and easy procedure provides a transition-metal-free alternative for the formation of 3-aryl coumarin derivatives at room temperature with good to excellent yields. This journal is

Visible-light-driven copper-catalyzed aerobic oxidative cascade cyclization of N-tosylhydrazones and terminal alkynes: Regioselective synthesis of 3-arylcoumarins

We present the first example of sustainable, intuitive, highly regioselective, visible-light-driven copper catalyzed aerobic oxidative cascade cyclization of N-tosylhydrazones with terminal alkynes for the preparation of 3-arylcoumarins at room temperature. This operationally simple methodology has been successfully applied to a wide range of N-tosylhydrazones and alkynes (49 examples), and proceeds well to afford biologically active compounds, such as monoamine oxidase B (MAO-B) inhibitor and horseradish peroxidase (HRP) inhibitor, in satisfactory yields under mild conditions. Furthermore, mechanistic studies suggest that the reaction proceeds via a copper(ii)-superoxo or -peroxo complex mediated oxidative annulation of terminal alkynes, as evidenced by 18O2 isotopic-labelling experiments.

Regioselective C-3 arylation of coumarins with arylhydrazines via radical oxidation by potassium permanganate

An efficient protocol for oxidative C-3 arylation of coumarins with arylhydrazine has been developed using potassium permanganate as an oxidant. The arylated coumarins with different electronic properties were obtained in moderate to good yields. The deve