2303-23-3

Basic information

• Product Name: 3-CHLOROPHENYL-4-NITROPHENYL ETHER
• Synonyms: 1-chloro-3-(4-nitrophenoxy)benzene;3’-chloro-4-nitrobiphenylether;3-chlorophenyl4’-nitrophenylether;ether,m-chlorophenylp-nitrophenyl;3MONOCHLOROPHENYL4NITROPHENYLETHER;4-Nitrophenyl 3-chlorophenyl ether;m-Chlorophenyl(p-nitrophenyl) ether
• CAS NO: 2303-23-3
• Molecular Formula: C₁₂H₈ClNO₃
• Molecular Weight: 249.64982
• Mol File: 2303-23-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 350.7°Cat760mmHg
• Flash Point: 165.9°C
• Appearance: /
• Density: 1.358g/cm³
• Vapor Pressure: 8.73E-05mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 3-CHLOROPHENYL-4-NITROPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROPHENYL-4-NITROPHENYL ETHER(2303-23-3)
• EPA Substance Registry System: 3-CHLOROPHENYL-4-NITROPHENYL ETHER(2303-23-3)

Safety Data

• Hazardous Substances Data: 2303-23-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H8ClNO3/c13-9-2-1-3-12(8-9)17-11-6-4-10(5-7-11)14(15)16/h1-8H

Upstream product

• 108-43-0 3-monochlorophenol 
• 586-78-7 para-nitrophenyl bromide 
• 22528-34-3 3-amino-4'-nitrodiphenyl ether 
• 126644-71-1 1-<(tert-butyldimethylsilyl)oxy>-3-chlorobenzene 
• 350-46-9 4-Fluoronitrobenzene 
• 22483-34-7 acetic acid-[3-(4-nitro-phenoxy)-anilide] 
• 76506-19-9 Potassium; 3-acetylamino-phenolate 

Downstream Products

• 56705-51-2 N-(5-amino-2-chlorophenyl)acetamide 

Relevant articles and documents

Diaryl ether compound, preparation method and application thereof

The invention relates to a diaryl ether compound , a preparation method and application thereof, wherein the diaryl ether compound has the following structural formula: (the formula is shown in the description), wherein, -X- is CH- or -N-; =R1,-R2,-R3 are independently selected from one kind of H-,-F,-Cl,-Br, alkoxy, aryl, aryloxy, N, N-Dialkylamino, N-Alkyl-N-Acylamino, pyridyl, imidazolyl, pyrazolyl, furyl, pyrrolyl, morpholinyl, N-Alkyl piperazinyl, piperidinyl and tetrahydropyrrolyl. The diaryl ether compound has the advantage of inhibiting the activity of a PFKFB3 in the tumor cells, effectively blocking the activation of the key enzyme during the glycolysis process, thereby blocking energy supply from the energy source of the tumor cells, and providing a new medicament for the effective treatment of the tumor diseases.

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Structure-based virtual screening of a commercial library identified pentanedioic acid derivatives (6 and 13b) as a kind of novel scaffold farnesyltransferase inhibitors (FTIs). Chemical modifications of the lead compounds, biological assays and analysis of the structure-activity relationships (SAR) were conducted to discover more potent FTIs. Some of them displayed excellent inhibition against FTase, and among them, the most active compound 13n with an IC50 value of 0.0029 μM and SAR analysis might be helpful to the discovery of more potent FTIs. This journal is

P(i-BuNCH2CH2)3N: An efficient promoter for the nucleophilic aromatic substitution reaction of aryl fluorides with aryl TBDMS (or TMS) ethers

(Chemical Equation Presented) The nucleophilic aromatic substitution reaction between electron-deficient aryl fluorides and aryl TBDMS (or TMS) ethers has been shown to be efficiently promoted by proazaphosphatranes such as P(i-BuNCH2CH2)3N (3). Excellent yields of diaryl ether products were obtained under unusually mild conditions.