230300-07-9Relevant articles and documents
Potent HIV protease inhibitors containing a novel (2-Phenylsulfanyl-1-Hydroxyethyl)amide isostere
Rocheblave,Priem,De Michelis,Kraus
, p. 4173 - 4176 (2007/10/03)
Based on the concept of bioisosterism, we report the design and synthesis of new protease inhibitors. These new compounds incorporate in their backbone the synthon 2-N-Acyl-2-Phenylsulfanyl-1-Hydroxyethyl (I) which confers on the resulting compounds both