23037-61-8

Basic information

• Product Name: 1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol
• Synonyms: 1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol
• CAS NO: 23037-61-8
• Molecular Weight: 210.273
• Mol File: 23037-61-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol(23037-61-8)
• EPA Substance Registry System: 1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol(23037-61-8)

Safety Data

• Hazardous Substances Data: 23037-61-8(Hazardous Substances Data)

Usage

Description

1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol, also known as 2-methyl-1-(3,4-dimethoxyphenyl)propan-2-ol, is a chemical compound with the molecular formula C12H18O3. It is a colorless, volatile liquid characterized by a pleasant odor. 1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol is notable for its aromatic properties due to the presence of a phenyl and dimethoxy group in its structure, making it a significant player in the fragrance industry. Beyond its use in fragrances, it also serves as a solvent and an intermediate in the synthesis of other organic compounds, with potential applications in pharmaceutical and chemical research.

Uses

Used in Fragrance Industry:
1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol is used as a fragrance ingredient for its pleasant odor and aromatic properties, contributing to the scent profiles of perfumes and personal care products.
Used in Solvent Applications:
As a solvent, 1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol is utilized in various chemical processes to dissolve and mix with other substances, facilitating reactions and product formation.
Used in Organic Synthesis:
1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol is used as an intermediate in the synthesis of other organic compounds, playing a crucial role in creating a range of chemical products.
Used in Pharmaceutical and Chemical Research:
Due to its unique structure and properties, 1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol has potential applications in pharmaceutical and chemical research, where it can be explored for the development of new drugs and chemical processes.

Upstream product

• 67-64-1 acetone 
• 776-99-8 3,4-dimethoxyphenylacetone 
• 75-16-1 methylmagnesium bromide 
• 917-64-6 methyl magnesium iodide 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 

Downstream Products

• 132681-01-7 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinoline 
• 121064-15-1 1,3,3-trimethyl-6,7-dimethoxy-3,4-dihydroisoquinoline 
• 121064-20-8 6,7-Dimethoxy-1,2,3,3-tetramethyl-3,4-dihydro-isoquinolinium; iodide 
• 1222887-74-2 (E)-1-(2-(hex-1-enyl)-4,5-dimethoxyphenyl)-2-methylpropan-2-ol 
• 1222887-36-6 (Z)-1-(ethylsulfonylmethylene)-6,7-dimethoxy-3,3-dimethylisochroman 
• 1222887-66-2 (E)-1-(2-(2-(ethylsulfonyl)vinyl)-4,5-dimethoxyphenyl)-2-methylpropan-2-ol 
• 1222887-65-1 methyl 5-(2-(2-hydroxy-2-methylpropyl)-4,5-dimethoxyphenyl)cyclopent-1-enecarboxylate 
• 1222887-67-3 (E)-phenyl 2-(2-(2-hydroxy-2-methylpropyl)-4,5-dimethoxyphenyl)ethenesulfonate 

Relevant articles and documents

Radical dehydroxylative alkylation of tertiary alcohols by Ti catalysis

Deoxygenative radical C?C bond-forming reactions of alcohols are a long-standing challenge in synthetic chemistry, and the current methods rely on multistep procedures. Herein, we report a direct dehydroxylative radical alkylation reaction of tertiary alcohols. This new protocol shows the feasibility of generating tertiary carbon radicals from alcohols and offers an approach for the facile and precise construction of all-carbon quaternary centers. The reaction proceeds with a broad substrate scope of alcohols and activated alkenes. It can tolerate a wide range of electrophilic coupling partners, including allylic carboxylates, aryl and vinyl electrophiles, and primary alkyl chlorides/bromides, making the method complementary to the cross-coupling procedures. The method is highly selective for the alkylation of tertiary alcohols, leaving secondary/primary alcohols (benzyl alcohols included) and phenols intact. The synthetic utility of the method is highlighted by its 10-g-scale reaction and the late-stage modification of complex molecules. A combination of experiments and density functional theory calculations establishes a plausible mechanism implicating a tertiary carbon radical generated via Ti-catalyzed homolysis of the C?OH bond.

Hypervalent iodine(III)-induced intramolecular cyclization reaction of substituted phenol ethers with an alkyl azido side-chain: A novel and efficient synthesis of quinone imine derivatives

Novel and efficient syntheses of quinone imine ketals (2aj) and quinone imines (4ah) from substituted phenol ethers (1ak) bearing an alkyl azido side-chain using the combination of hypervalent iodine(III) reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA) and trimethylsilyl trifluoromethanesulfonate (TMSOTf), have been developed.