23042-75-3

Basic information

• Product Name: N-(2,4-dimethoxyphenyl)acetamide
• Synonyms: N-(2,4-dimethoxyphenyl)acetamide;EINECS 245-394-7;1-(Acetylamino)-2,4-dimethoxybenzene;2',4'-Dimethoxyacetanilide;Acetamide, N-(2,4-dimethoxyphenyl)-
• CAS NO: 23042-75-3
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.21512
• EINECS: 245-394-7
• Product Categories: Amines, Aromatics, Miscellaneous Reagents
• Mol File: 23042-75-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 117 °C(Solv: ethanol (64-17-5))
• Boiling Point: 350.3°Cat760mmHg
• Flash Point: 165.6°C
• Appearance: /
• Density: 1.144g/cm³
• Vapor Pressure: 4.44E-05mmHg at 25°C
• Refractive Index: 1.544
• PKA: 13.90±0.70(Predicted)
• CAS DataBase Reference: N-(2,4-dimethoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-dimethoxyphenyl)acetamide(23042-75-3)
• EPA Substance Registry System: N-(2,4-dimethoxyphenyl)acetamide(23042-75-3)

Safety Data

• Hazardous Substances Data: 23042-75-3(Hazardous Substances Data)

Usage

Description

N-(2,4-dimethoxyphenyl)acetamide is an organic compound that features a phenyl group with two methoxy substituents at the 2nd and 4th positions, attached to an amide functional group. This chemical structure endows it with specific reactivity and properties that make it useful in various chemical reactions and applications.

Uses

Used in Chemical Synthesis:
N-(2,4-dimethoxyphenyl)acetamide is used as a reactant for the synthesis of regioselective halogenation of aromatic compounds. Its presence in the reaction mixture aids in achieving a specific orientation of the halogen atom on the aromatic ring, which is crucial for the subsequent reactions and the desired product's properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-(2,4-dimethoxyphenyl)acetamide may be utilized as an intermediate in the synthesis of various drugs and pharmaceutical compounds. Its unique structure can be further modified to create molecules with specific biological activities, contributing to the development of new medications.
Used in Material Science:
The compound may also find applications in material science, particularly in the development of novel materials with tailored properties. Its ability to participate in specific chemical reactions can lead to the creation of new polymers, coatings, or other materials with improved characteristics.

InChI:InChI=1/C10H13NO3/c1-7(12)11-9-5-4-8(13-2)6-10(9)14-3/h4-6H,1-3H3,(H,11,12)

Upstream product

• 5307-06-2 N-(4-hydroxy-2-methoxyphenyl)acetamide 
• 77-78-1 dimethyl sulfate 
• 26053-96-3 4-acetoxy-4'-methoxyazobenzene 
• 75-18-3 dimethylsulfide 
• 128317-40-8 N-methoxy-N-(4-methoxyphenyl)acetamide 
• 108-24-7 acetic anhydride 
• 2735-04-8 2,4-Dimethoxyaniline 
• 75-36-5 acetyl chloride 
• 150-19-6 O-methylresorcine 
• 106063-48-3 4-benzenesulfonic acid 
• 61638-01-5 4-Amino-3-methoxyphenol 
• 72-89-9 acetylcoenzyme A 

Downstream Products

• 99075-67-9 thioacetic acid-(2,4-dimethoxy-anilide) 
• 76030-55-2 (2,4-dimethoxyphenyl)methanamine 
• 857950-16-4 2,4-dimethoxy-5-nitroacetanilide 
• 2735-04-8 2,4-Dimethoxyaniline 
• 78149-72-1 3-(2,4-Dimethoxy-5-(methylcarboxamido)benzoyl)acrylic Acid 
• 121638-90-2 (acetamido-5 hydroxy-2 methoxy-4 phenyl) (thienyl-2)methanone 
• 121638-93-5 (acetamido-5 dimethoxy-2,4 phenyl) (thienyl-2)methanone 
• 68047-36-9 6-amino-7-hydroxy-4-methyl-2H-chromen-2-one 
• 121638-89-9 (amino-5 hydroxy-2 methoxy-4 phenyl) (thienyl-2)methanone 
• 121638-92-4 (5-Amino-2,4-dimethoxy-phenyl)-thiophen-2-yl-methanone 
• 121638-91-3 Acetic acid 4-acetylamino-5-methoxy-2-(thiophene-2-carbonyl)-phenyl ester 
• 78149-75-4 2-(2,4-Dimethoxy-5-(methylcarboxamido)benzoyl)-4-methyl-4-cyclohexenecarboxylic Acid 
• 101908-41-2 2-chloro-N-(2,4-dimethoxyphenyl)acetamide 
• 1381862-04-9 N-acetyl-2-methoxy-p-benzoquinone imine dimethyl acetal 

Relevant articles and documents

Evaluation of DIMBOA analogs as antifeedants and antibiotics towards the aphid Sitobion avenae in artificial diets

A total of 25 compounds including benzoxazinones, benzoxazolinones, and N-glyoxylamide derivatives were tested as antifeedants and antibiotics towards the aphid Sitobion avenae in diet bioassays. The antifeedant and mortality indexes increased with the presence of electron-donating groups in the 7 position of the benzoxazinone moiety, the replacement of the oxygen atom by sulfur in the heterocyclic ring, the presence of a hemiacetal instead of an acetal at C-2 of the benzoxazine moiety (and hence the possibility of ring opening), and the presence of a hydroxyl group at C-4 of the benzoxazine moiety (hydroxamic acid) instead of a hydrogen atom (lactam). The results support earlier hypotheses on the chemical bases for the mode of action of these compounds.

Isoxazole sulfonamides compound with BRD4 inhibitory activity and preparation method and application thereof

The invention provides an isoxazole sulfonamide compound with BRD4 inhibitory activity or a pharmaceutically acceptable salt thereof, and the compound has the structural formula shown in the general formula (I). The invention further provides an application of the compound or a pharmaceutically acceptable salt or the pharmaceutical composition in preparation of a medicament for preventing or treating cancer related to BRD4, wherein the cancer comprises leukemia. The lymphoma, myeloma, lung cancer, prostate cancer, pancreatic cancer, colon cancer, breast cancer, liver cancer, gastric cancer, and the like. The invention provides a novel BRD4 inhibitor, and experiments prove that the novel compound has a 3 - ethyl benzo [d] isoxazole sulfonamide structure and has a good BRD4 protein inhibition effect and an in-vitro tumor cell inhibition effect. The compounds can also effectively inhibit the expression of c-Myc oncogenes.

METHOD FOR SYNTHESISING AMIDES

The present invention relates to a method for synthesising amides that is of general applicability. The method may be performed in vitro or in vivo. Cell lines for use in the in vivo methods also form aspects of the invention. The method for synthesising a non-natural amide comprises: a. reaction of a carboxylic acid with a naturally occurring CoA ligase or a variant thereof; and b. reaction of the product of step a with an amine in the presence of a naturally occurring acyltransferase or a variant thereof; with the proviso that where the CoA ligase and acyltransferase are both naturally occurring, they are not derived from the same source species and do not act sequentially in a metabolic pathway; and with the proviso that the non-natural product is not N-(E)-p-coumaroyl-3-hydroxyanthranilic acid or N-(E)-p-caffeoyl-3-hydroxyanthranilic acid. Further, a method for producing an active pharmaceutical ingredient by the aforementioned method and host cells for carrying out said methods are envisaged.

A kind of benzo [d] different wicked zuozuo apperception compound and use thereof

The invention relates to the technical field of chemical medicine, and particularly discloses a benzo[d]isoxazole compound shown as a general formula (A) and application thereof. The compound can effectively inhibit bromodomain of BET family proteins so as to block interaction between the BET family proteins and chromatin histone to adjust genetic transcription, cause changing of a downstream signal path and exert important influence on various diseases, so that the compound and a combination thereof can be used for preparing medicine for treating or preventing diseases like tumorigenesis, inflammation, viral infection, cell proliferation disorder, autoimmune diseases and septicemia.