2305-25-1 Usage
Description
ETHYL 3-HYDROXYHEXANOATE is a colorless clear liquid that is a fatty acid ester, specifically the ethyl ester of 3-hydroxyhexanoic acid. It is characterized by its fruity odor and contributes to the scent and flavor profile of various fruits such as guava, bananas, and citrus fruits.
Uses
Used in Flavor and Fragrance Industry:
ETHYL 3-HYDROXYHEXANOATE is used as a flavoring agent for its sweet, fruity, and grape-like taste with citrus notes, particularly at a concentration of 80 ppm. It is commonly found in the natural aroma of fruits like guava, bananas, and citrus fruits.
Used in Beverage Industry:
ETHYL 3-HYDROXYHEXANOATE is used as a flavor enhancer in the production of beverages such as cognac, Scotch whiskey, red and white wine, and fruit juices like orange, grapefruit, and tangerine juice. It helps to create a more complex and appealing taste profile in these drinks.
Used in Food Industry:
ETHYL 3-HYDROXYHEXANOATE is used as an additive in the food industry to impart a sweet, fruity, and citrusy flavor to various products. It can be found in the natural composition of fruits like pineapple, strawberry, passion fruit, mango, quince, wood apple, mountain papaya, pawpaw, and hog plum (Spondias mombins L.).
Used in Perfumery:
ETHYL 3-HYDROXYHEXANOATE is used as a fragrance ingredient in the perfumery industry due to its fruity odor, which can add depth and complexity to various scent compositions.
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 269, 1974 DOI: 10.1021/jo00916a043
Check Digit Verification of cas no
The CAS Registry Mumber 2305-25-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,0 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2305-25:
(6*2)+(5*3)+(4*0)+(3*5)+(2*2)+(1*5)=51
51 % 10 = 1
So 2305-25-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H16O3/c1-3-5-7(9)6-8(10)11-4-2/h7,9H,3-6H2,1-2H3/t7-/m0/s1
2305-25-1Relevant articles and documents
Organic Sonochemistry. Sonic Acceleration of the Reformatsky Reaction
Han, Byung-Hee,Boudjouk, Philip
, p. 5030 - 5032 (1982)
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Synthesis method of ethyl 3-hydroxyhexanoate
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Paragraph 0017; 0020; 0021; 0024; 0025; 0028; 0029; 0032, (2020/02/27)
The invention discloses a synthesis method of ethyl 3-hydroxyhexanoate. The method is characterized by comprising the following steps: reacting bromine with acetic acid to prepare bromoacetic acid; reacting the bromoacetic acid with ethanol in the presence of sulfuric acid to generate ethyl bromoacetate; adding 500kg of dichloromethane and 140kg of n-butyraldehyde into a reaction kettle; adding acatalyst, heating to reflux, dropwise adding 250kg of the ethyl bromoacetate serving as a product obtained in the previous step, controlling the dropwise adding speed, controlling the adding to be completed within 3 hours in a reflux state, preserving heat for 2 hours, cooling to room temperature, washing to neutrality, transferring into a rectifying tower, and rectifying to obtain a qualified product, namely the ethyl 3-hydroxyhexanoate.
Synthesis of Thelepamide via Catalyst-Controlled 1,4-Addition of Cysteine Derivatives and Structure Revision of Thelepamide
Seitz, Tobias,Millán, Ramón E.,Lentz, Dieter,Jiménez, Carlos,Rodríguez, Jaime,Christmann, Mathias
supporting information, p. 594 - 597 (2018/02/10)
The first enantioselective total synthesis and structural reassignment of (-)-thelepamide, a cytotoxic tetraketide-amino acid from the marine worm Thelepus crispus, is reported. A convergent approach provides access to all thelepamide diastereomers in six steps from four simple building blocks. Key features of the synthesis include the application of Melchiorre's organocatalytic thia-Michael reaction and a sonication-assisted assembly of an unprecedented N,O-acetal-hemiacetal moiety. The corrected structure was confirmed by NMR-DFT analysis.
