2305-70-6

Basic information

• Product Name: 4-Hydroxyquinoline-3-carbonitrile
• Synonyms: 3-Quinolinecarbonitrile, 4-hydroxy-;4-Hydroxy-3-quinolinecarbonitrile
• CAS NO: 2305-70-6
• Molecular Formula: C₁₀H₆N₂O
• Molecular Weight: 170.17
• Mol File: 2305-70-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 299.8°C at 760 mmHg
• Flash Point: 135.1°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 0.00117mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: 4-Hydroxyquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxyquinoline-3-carbonitrile(2305-70-6)
• EPA Substance Registry System: 4-Hydroxyquinoline-3-carbonitrile(2305-70-6)

Safety Data

• Hazardous Substances Data: 2305-70-6(Hazardous Substances Data)

Usage

General Description

4-Hydroxyquinoline-3-carbonitrile, also known as 4-Hydroxy-3-cyanopyridine, is a chemical compound with the molecular formula C10H6N2O. It is a pale yellow crystalline powder that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 4-Hydroxyquinoline-3-carbonitrile is known for its versatile properties, including its ability to act as a chelating agent, a precursor in heterocyclic chemistry, and a building block in ligand design. It is a key ingredient in the production of a wide range of products, making it an important chemical in the field of organic synthesis.

InChI:InChI=1/C10H6N2O/c11-5-7-6-12-9-4-2-1-3-8(9)10(7)13/h1-4,6H,(H,12,13)

Upstream product

• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 56-57-5 4-nitroquinoline-N-oxide 
• 2305-54-6 2-(Anilinomethylen)-2-cyanessigsaeure-ethylester 

Downstream Products

• 69875-49-6 4-chlro-3-cyanoquinoline 

Relevant articles and documents

Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Intramolecular thermal cyclization and benzannulation reactions of the Gould-Jacobs and Conrad-Limpach types were performed in a designed continuous flow reactor system at temperatures in the range of 300-360°C and under high pressure conditions (100-160 bar) with very short residence times (0.45-4.5 min) in tetrahydrofuran as a low-boiling point solvent. Substituted heteroaromatic compounds including pyridopyrimidinones and hydroxyquinolines were synthesized in moderate to high yields. Application of the reaction conditions also allows the synthesis of naphthol and biphenyl derivatives. The procedure involves an easy work-up and the non-batchwise preparative synthesis method is suitable for automation.

Pyridine and related aza heterocycle derivatives as cardiovascular agents

Novel pharmaceutical compounds and compositions having nitrogen containing ring systems which may be represented by the following structural formula: wherein R1 or R3 is a moiety of the formula: wherein R6 is selected from either hydrogen or acetyl; R7 is selected from 2, 3 or 4-pyridyl or 1-imidazolyl and Q is -(CH2)n, where n is an integer from 1 to 5 and R1 and R2, R2 and R3, R3 and R4 or R4 and R5 taken together may be -CH=CH-CH=CH-. The compounds and compositions are useful as inhibitors of thromboxane synthetase and in the treatment of hypertension and arrythmia in mammals.