23126-82-1

Basic information

• Product Name: N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE
• Synonyms: N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE;AKOS BBS-00003135;6-Chloro-N-methyl-5-nitro-4-pyrimidinamine
• CAS NO: 23126-82-1
• Molecular Formula: C₅H₅ClN₄O₂
• Molecular Weight: 188.57
• Mol File: 23126-82-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 134 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE(23126-82-1)
• EPA Substance Registry System: N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE(23126-82-1)

Safety Data

• Hazardous Substances Data: 23126-82-1(Hazardous Substances Data)

Usage

General Description

N4-Methyl-6-chloro-5-nitropyrimidin-4-amine is a chemical compound with the molecular formula C6H6ClN5O2. It is a nitro-substituted pyrimidine derivative, with a nitro group at the 5-position and a methyl and chloro group at the 4 and 6 positions, respectively. N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE is potentially used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It may also have applications in the field of medicinal chemistry and biological research. Additionally, it is important to handle N4-Methyl-6-chloro-5-nitropyrimidin-4-amine with caution due to its potentially hazardous nature, and it should be used and stored in accordance with proper safety protocols and regulations.

Upstream product

• 123-91-1 1,4-dioxane 
• 4316-93-2 4,6-dichloro-5-nitropyrimidine 
• 64-19-7 acetic acid 
• 74-89-5 methylamine 

Downstream Products

• 100114-07-6 (6-methoxy-5-nitro-pyrimidin-4-yl)-methyl-amine 
• 91184-45-1 methyl-thiazolo[5,4-d]pyrimidin-7-yl-amine 
• 13784-17-3 5-amino-4-methylaminopyrimidine 
• 52602-68-3 6-chloro-N⁴-methylpyrimidine-4,5-diamine 

Relevant articles and documents

Palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines with amines

A concise and efficient approach was developed for the synthesis of mono-substituted and di-substituted pyrimidines products via palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines and amines. This synthetic methodology can produce vari

Novel 8-arylated purines as inhibitors of glycogen synthase kinase

A series of 8-arylated purine derivatives bearing either an aniline or an alkyl amide at position 6 were found to inhibit glycogen synthase kinase-3,with good selectivity over ten kinases. Molecular modeling studies indicated that the most active compounds (8a and 8e),adopt a planar conformation,close to the shape of AMPPNP in the crystal structure of GSK-3. These compounds are stabilized by hydrophobic contacts between the 8-aromatic group and the protein adenine pocket and by electrostatic contacts.

Purines, Pyrimidines, and Imidazoles. Part 61. Reaction of 6-Alkylamino-4-chloro-5-nitropyrimidines with Diethyl Malonate, Ethyl Cyanoacetate, and Ethyl Acetoacetate and some derived Pyrrolopyrimidines related to the Cytokinins

Reaction of 4-chloro-6-methylamino-5-nitropyrimidine (3d) with diethyl malonate and sodium hydroxide afforded diethyl 6-methylamino-5-nitropyrimidin-4-ylmalonate which was reduced to diethyl 5-amino-6-methylaminopyrimidin-4-ylmalonate and this, with sodiu