2314-77-4

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(2-methoxyphenyl)-
• CAS NO: 2314-77-4
• Molecular Formula: C15H11NO3
• Molecular Weight: 253.257
• Mol File: 2314-77-4.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-methoxyphenyl)-(2314-77-4)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(2-methoxyphenyl)-(2314-77-4)

Safety Data

• Hazardous Substances Data: 2314-77-4(Hazardous Substances Data)

Usage

Chemical compound

2-(2-methoxyphenyl)-1H-Isoindole-1,3(2H)-dione is a chemical compound that is a derivative of isoindole-1,3(2H)-dione.

Versatile applications

The compound has a variety of potential applications, including in pharmaceuticals, agrochemicals, and materials science.

Methoxyphenyl substituent

The compound features a methoxyphenyl substituent at the 2-position, which may contribute to its versatile applications.

Pharmaceutical properties

2-(2-methoxyphenyl)-1H-Isoindole-1,3(2H)-dione has been studied for its potential pharmaceutical properties, including its anti-inflammatory and analgesic effects.

Building block in organic synthesis

The compound has been investigated for its potential use as a building block in organic synthesis for the production of various pharmaceuticals and agrochemicals.

Materials science

2-(2-methoxyphenyl)-1H-Isoindole-1,3(2H)-dione has been studied for its potential use in materials science, particularly in the development of organic semiconducting materials for use in electronic devices.

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 609-67-6 2-Iodobenzoyl chloride 
• 64-18-6 formic acid 
• 36684-47-6 2-iodo-N-(2-methoxy-phenyl)-benzamide 
• 62-53-3 aniline 
• 520-03-6 N-phenylphthalimide 
• 6307-13-7 2-(2-hydroxyphenyl) isoindoline-1,3-dione 
• 74-88-4 methyl iodide 
• 136918-14-4 phthalimide 
• 83724-41-8 tris(2-methoxyphenyl)bismuthine 
• 90-04-0 2-methoxy-phenylamine 
• 201230-82-2 carbon monoxide 
• 100-66-3 methoxybenzene 
• 3481-09-2 N-chlorophthalimide 

Downstream Products

• 19336-96-0 2-((2-methoxyphenyl)carbamoyl)benzoic acid 
• 108444-18-4 3-hydroxy-2-(2-methoxyphenyl)isoindolin-1-one 
• 5395-00-6 N-(2-methoxyphenyl)benzamide 
• 90-04-0 2-methoxy-phenylamine 
• 1025774-93-9 C₁₉H₂₀N₂O₄ 

Relevant articles and documents

Equivalent Loading of Directed Arenes in Pd(II)-Catalyzed Oxidative Cross-Coupling of Aryl C-H Bonds at Room Temperature

The unsymmetrical biaryls (Ar1-Ar2) produced by the catalytic cross-couplings of aryl halides (Ar1-halo) with aryl metallics (Ar2-M) in the loading ratio of 1:1 are popular in chemical synthesis. In contrast, there has been less precedence on the same biaryls produced effectively from two normal aryl C-H bonds with equivalent loading. Here, we report that, in a palladium/oxidant/acid catalytic system at room temperature, one arene (Ar1-H, 1 equiv) can highly selectively couple with the other one (Ar2-H, 1 equiv) to afford the target Ar1-Ar2 just by controlling the directing groups and the substituted groups on their phenyl rings. The utility of this one-one cross-coupling is also demonstrated by synthesis of a few bioactive molecules.

PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides

A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80 °C and furnishes the desired products in good to excellent yields.

Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives

The unprecedented transformation of a wide range of synthetically appealing phthalimides into amides in a single-step operation has been achieved in high yields and short reaction times using a ruthenium catalyst. Mechanistic studies revealed a unique, homogeneous pathway involving five-membered ring opening and CO2 release with water being the source of protons.