23195-59-7

Basic information

• Product Name: 5-(4-chlorophenyl)-1H-1,2,4-triazole
• Synonyms: 1H-1,2,4-triazole, 3-(4-chlorophenyl)-; 3-(4-Chlorophenyl)-1H-1,2,4-triazole
• CAS NO: 23195-59-7
• Molecular Formula: C₈H₆ClN₃
• Molecular Weight: 179.6063
• Mol File: 23195-59-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 358.5°C at 760 mmHg
• Flash Point: 201.9°C
• Density: 1.366g/cm³
• Vapor Pressure: 2.54E-05mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: 5-(4-chlorophenyl)-1H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)-1H-1,2,4-triazole(23195-59-7)
• EPA Substance Registry System: 5-(4-chlorophenyl)-1H-1,2,4-triazole(23195-59-7)

Safety Data

• Hazardous Substances Data: 23195-59-7(Hazardous Substances Data)

Usage

General Description

5-(4-chlorophenyl)-1H-1,2,4-triazole is a chemical compound with the molecular formula C8H6ClN3. It is a triazole compound with a 1,2,4-triazole core and a 4-chlorophenyl group attached to the 5-position. 5-(4-chlorophenyl)-1H-1,2,4-triazole is often used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It has also been studied for its potential antifungal and antitumor activities. Additionally, it has been shown to have inhibitory effects on the enzyme cytochrome P-450 19, which is involved in the biosynthesis of estrogen and androgen. Overall, 5-(4-chlorophenyl)-1H-1,2,4-triazole has a diverse range of potential applications in the fields of medicine, agriculture, and biochemistry.

Upstream product

• 26028-65-9 5-(4-chloro-phenyl)-1,2-dihydro-[1,2,4]triazole-3-thione 
• 83326-46-9 2-(4-Chloro-phenyl)-6-imino-1-phenyl-1,6-dihydro-pyrimidine-5-carbonitrile 
• 64310-32-3 1-(4-chlorobenzoyl)thiosemicarbazide 
• 122-01-0 4-chloro-benzoyl chloride 
• 16794-67-5 p-chlorobenzoyl isothiocyanate 
• 623-03-0 4-Cyanochlorobenzene 
• 64-18-6 formic acid 
• 619-56-7 4-chlorobenzamide 
• 54682-96-1 N-(1,2,2,2-tetrachloroethyl)-4-chlorobenzimidoyl chloride 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 64781-78-8 3-diazo-3H-[1,2,4]triazole 
• 108-90-7 chlorobenzene 

Downstream Products

• 1233852-50-0 3-(4-chlorophenyl)-N-methyl-N-phenyl-1H-1,2,4-triazole-1-carboxamide 

Relevant articles and documents

Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity

A series of novel tetrahydropyrazolopyridone derivatives containing 1,3,4-triazole, triazolylmethyl, and partially saturated heterocyclic moieties as P2 binding element was designed, synthesized, and evaluated in vitro for anticoagulant activity in human and rabbit plasma. All compounds showed moderate to significant potency, and compounds 15b, 15c, 20b, 20c, and 22b were further examined for their inhibitory activity against human FXa in vitro. While compounds 15c and 22b were tested for rat venous thrombosis in vivo. The most promising compound 15c, with an IC50 (FXa) value of 0.14?μM and 98% inhibition rate, warranted further investigation as an FXa inhibitor.

PHARMACEUTICAL COMPOUNDS

The invention relates to compounds and compositions for inhibiting the enzyme fatty acid amide hydrolase (FAAH), the use of the compounds in therapy and, in particular, for treating or preventing conditions whose development or symptoms are linked to subs

SUBSTITUENT AND COORDINATION EFFECTS IN SINGLET REACTIONS OF 3-DIAZO-3H-1,2,4-TRIAZOLES WITH SUBSTITUTED BENZENES AND NITRO COMPOUNDS

3-Diazo-3H-1,2,4-triazoles convert to singlet 3H-1,2,4-triazol-3-ylidenes which (1) effect directed electrophilic substitutions of benzenes and (2) coordinate with benzenoid substituents and nitro compounds to give decomposition or rearrangement products.