23197-67-3 Usage
Description
DIETHYL 4-METHOXYPHENYL MALONATE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its chemical structure, which includes a malonate group and a 4-methoxyphenyl group attached to it. DIETHYL 4-METHOXYPHENYL MALONATE plays a significant role in the development of new drugs and the understanding of their structure-activity relationships.
Uses
Used in Pharmaceutical Synthesis:
DIETHYL 4-METHOXYPHENYL MALONATE is used as an intermediate in the synthesis of 4-hydroxy felbamate (H942470), a compound with potential pharmaceutical applications. Its role in this process is essential for the development of new drugs and therapies.
Used in Medicinal Chemistry Research:
DIETHYL 4-METHOXYPHENYL MALONATE is used as a reagent in evaluating the structure-activity relationships of non-nucleoside adenosine kinase inhibitors of aminoarylarylethynylpyrimidines. This application helps researchers understand how the compound's structure affects its biological activity, which is crucial for the design and development of more effective drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 23197-67-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,1,9 and 7 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 23197-67:
(7*2)+(6*3)+(5*1)+(4*9)+(3*7)+(2*6)+(1*7)=113
113 % 10 = 3
So 23197-67-3 is a valid CAS Registry Number.
23197-67-3Relevant articles and documents
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De Gee et al.
, p. 3407,3411 (1969)
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Radical Addition Enables 1,2-Aryl Migration from a Vinyl-Substituted All-Carbon Quaternary Center
Li, Zexian,Shi, Zhuangzhi,Wang, Minyan
supporting information, p. 186 - 190 (2020/11/02)
An efficient method for photocatalytic perfluoroalkylation of vinyl-substituted all-carbon quaternary centers involving 1,2-aryl migration has been developed. The rearrangement reactions use fac-Ir(ppy)3, visible light and commercially available fluoroalkyl halides and can generate valuable multisubstituted perfluoroalkylated compounds in a single step that would be challenging to prepare by other methods. Mechanistically, the photoinduced alkyl radical addition to an alkene leads to the migration of a vicinal aryl substituent from its adjacent all-carbon quaternary center with the concomitant generation of a C-radical bearing two electron-withdrawing groups that is further reduced by a hydrogen donor to complete the domino sequence.
OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS
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Paragraph 0142; 0143; 0198, (2018/07/29)
Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.
