2321-50-8

Basic information

• Product Name: methyl 2-[(phenylcarbamoyl)amino]benzoate
• Synonyms: Benzoic acid, 2-[[(phenylamino)carbonyl]amino]-, methyl ester; Methyl 2-[(phenylcarbamoyl)amino]benzoate
• CAS NO: 2321-50-8
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.2833
• Mol File: 2321-50-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 337°C at 760 mmHg
• Flash Point: 157.6°C
• Density: 1.3g/cm³
• Vapor Pressure: 0.000108mmHg at 25°C
• Refractive Index: 1.661
• CAS DataBase Reference: methyl 2-[(phenylcarbamoyl)amino]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[(phenylcarbamoyl)amino]benzoate(2321-50-8)
• EPA Substance Registry System: methyl 2-[(phenylcarbamoyl)amino]benzoate(2321-50-8)

Safety Data

• Hazardous Substances Data: 2321-50-8(Hazardous Substances Data)

Upstream product

• 103-71-9 phenyl isocyanate 
• 134-20-3 2-carbomethoxyaniline 
• 101-99-5 N-carboethoxyaniline 
• 62-53-3 aniline 

Downstream Products

• 603-23-6 3-phenyl-2,4-(1H,3H)-quinazolinedione 
• 1026-16-0 2-(phenylamino)-4H-benzo[d][1,3]oxazin-4-one 

Relevant articles and documents

COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS

Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes.

Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton

Novel non-steroidal progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton were developed and their structure-activity relationships were investigated. Among the prepared compounds, 4-(4,4-diethyl-3,

Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.

Potent, specific, chemically stable and non-peptide/small-molecular inhibitors of puromycin-sensitive aminopeptidase, such as 3-(2,6-diethylphenyl)-2,4(1H,3H)-quinazolinedione (PAQ-22, 5), were prepared by the structural development of a potent PSA inhibitor, 2-(2,6-diethylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (PIQ-22, 4). The design was carried out partly by applying electrostatic potential field information obtained from PIQ-22 (4) and its derivatives based on thalidomide (2). This information revealed that a positive electrostatic potential field around the benzylic methylene in the tetrahydroisoquinoline ring is necessary for potent activity. Lineweaver-Burk plot analysis showed that PAQ-22 (5) and its derivatives inhibit puromycin-sensitive aminopeptidase (PSA) in a non-competitive manner. These potent and specific PSA inhibitors showed dose-dependent cell invasion-inhibitory activity in a Matrigel assay using mouse melanoma B16F10/L5 cells, in spite of their low cell toxicity.