23228-45-7Relevant articles and documents
Method for synthesizing 2-fluoro-4-trifluoromethylbenzoic acid
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Paragraph 0011, (2017/09/06)
The invention discloses a method for synthesizing 2-fluoro-4-trifluoromethylbenzoic acid. After chlorobenzotrifluoride serves as a raw material and undergoes selective proton abstraction together with 2,2,6,6-tetramethyl piperidine magnesium chloride or 2
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS
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Page/Page column 62, (2010/02/11)
The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.
Reagent-modulated optional site selectivities: The metalation of o-, m- and p-halobenzotrifluorides
Mongin,Desponds,Schlosser
, p. 2767 - 2770 (2007/10/03)
Chloro(trifluoromethyl)benzenes and bromo(trifluoromethyl)benzenes undergo deprotonation at a position adjacent to the single halogen substituent when treated with alkyllithiums (at -75°C) and, respectively, lithium 2,2,6,6-tetramethylpiperidide (at -100°C) in tetrahydrofuran. Positional ambiguities, if existing, can be exploited to establish optional site selectivities. Thus, butyllithium reacts with 1-chloro-3-(trifluoromethyl)benzene under hydrogen/metal interconversion at the 2-position whereas sec-butyllithium attacks exclusively the 6-position. The latter mode of regioselectivity is also exhibited by 1-bromo-3-(trifluoromethyl)benzene in the presence of lithium 2,2,6,6-tetramethylpiperidide, only 2-bromo-4-(trifluoromethyl)phenyllithium being produced. 2-Bromo-6-(trifluoromethyl)phenyllithium is directly inaccessible, but is formed when 2-bromo-3-(trifluoromethyl)phenyllithium, generated at -100°C, is allowed to isomerize at -75°C.