23267-57-4

Basic information

• Product Name: 4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one
• Synonyms: 4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one;4-(1,2-Epoxy-2,6,6-trimethylcyclohexyl)-3-buten-2-one;epoxy-β-ionone,5,6-epoxy-β-ionone;3-Buten-2-one, 4-(2,2,6-trimethyl-7-oxabicyclo4.1.0hept-1-yl)-;BETA-IONONEEPOXIDE;1-(3-Oxo-1-butenyl)-2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptane;1,2-Epoxy-2,6,6-trimethyl-1-(3-oxo-1-butenyl)cyclohexane;2,3-Epoxy-β-ionone
• CAS NO: 23267-57-4
• Molecular Formula: C₁₃H₂₀O₂
• Molecular Weight: 208.2967
• EINECS: 245-542-0
• Mol File: 23267-57-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 275.1°Cat760mmHg
• Flash Point: 103.7°C
• Appearance: /
• Density: 1.075g/cm³
• Vapor Pressure: 0.0052mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one(23267-57-4)
• EPA Substance Registry System: 4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one(23267-57-4)

Safety Data

• Hazardous Substances Data: 23267-57-4(Hazardous Substances Data)

Usage

Description

4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one is an apo carotenoid monoterpenoid, specifically beta-ionone, which is substituted by an epoxy group across positions 5 and 6. This chemical structure grants it unique properties and potential applications in various industries.

Uses

Used in Flavor and Fragrance Industry:
4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one is used as a key compound for creating unique and complex fragrances and flavors. Its distinct chemical structure allows it to contribute to the development of novel scents and tastes, enhancing the sensory experience in various products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one is utilized as an intermediate in the synthesis of various drugs and medicinal compounds. Its unique chemical properties make it a valuable building block for developing new therapeutic agents.
Used in Chemical Research:
4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one serves as an important research tool in the field of organic chemistry. Its unique structure allows scientists to study various chemical reactions and mechanisms, leading to a better understanding of chemical processes and the development of new synthetic methods.
Used in Material Science:
In the field of material science, 4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one can be used as a component in the development of novel materials with specific properties. Its unique chemical structure may contribute to the creation of materials with enhanced performance characteristics, such as improved stability, reactivity, or selectivity.
Overall, 4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-3-buten-2-one is a versatile compound with a wide range of potential applications across various industries, including flavor and fragrance, pharmaceutical, chemical research, and material science. Its unique chemical structure and properties make it a valuable asset in the development of new products and technologies.

InChI:InChI=1/C13H20O2/c1-10(14)6-9-13-11(2,3)7-5-8-12(13,4)15-13/h6,9H,5,7-8H2,1-4H3

Upstream product

• 79-77-6 (E)-β-ionone 
• 54795-77-6 β-ionone 
• 79-77-6 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one 

Downstream Products

• 65868-84-0 (Z)-4-(1,2,2-Trimethyl-6-oxo-cyclohexyl)but-3-en-2-on 
• 65912-37-0 (E)-4-(1,2,2-Trimethyl-6-oxo-cyclohexyl)-but-3-en-2-on 
• 55955-46-9 hydroxyionone 
• 65869-04-7 4-(1,2,2-Trimethyl-6-oxo-cyclohexyl)butan-2-on 

Relevant articles and documents

A further step to sustainable palladium catalyzed oxidation: Allylic oxidation of alkenes in green solvents

The palladium catalyzed oxidation of alkenes with molecular oxygen is a synthetically important reaction which employs palladium catalysts in solution; therefore, a solvent plays a critical role for the process. In this study, we have tested several green solvents as a reaction medium for the allylic oxidation of a series of alkenes. Dimethylcarbonate, methyl isobutyl ketone, and propylene carbonate, solvents with impressive sustainability ranks and very scarcely exploited in palladium catalyzed oxidations, were proved to be excellent alternatives for the solvents conventionally employed in these processes, such as acetic acid. Palladium acetate alone or in the combination with p-benzoquinone efficiently operates as the catalyst for the oxidation of alkenes by dioxygen under 5–10 atm. For most substrates, the systems in green solvents showed better selectivity for allylic oxidation products as compared to pure acetic acid; moreover, the reactions in propylene carbonate solutions occurred even faster than in acetic acid.

Synthesis, structural characterization and effect on human granulocyte intracellular cAMP levels of abscisic acid analogs

The phytohormone abscisic acid (ABA), in addition to regulating physiological functions in plants, is also produced and released by several mammalian cell types, including human granulocytes, where it stimulates innate immune functions via an increase of the intracellular cAMP concentration ([cAMP]i). We synthesized several ABA analogs and evaluated the structure-activity relationship, by the systematical modification of selected regions of these analogs. The resulting molecules were tested for their ability to inhibit the ABA-induced increase of [cAMP]i in human granulocytes. The analogs with modified configurations at C-2′ and C-3′ abrogated the ABA-induced increase of the [cAMP]i and also inhibited several pro-inflammatory effects induced by exogenous ABA on granulocytes and monocytes. Accordingly, these analogs could be suitable as novel putative anti-inflammatory compounds.

Non-heme iron catalysis in CC, C-H, and CH2 oxidation reactions. Oxidative transformations on terpenoids catalyzed by Fe(bpmen)(OTf)2

The oxidation of terpene olefins with hydrogen peroxide in the presence of the non-hemo catalyst 5a afforded mixtures of epoxides whose composition was dependent upon the oxidation protocol used in each case. With terpenoid enones, the mixtures obtained evolved from clean epoxidation of α-ionone 23 to the clean allylic oxidation of damascone 28 due to the progressive deactivation of the electron density on the double bonds present in this series. The oxidation of bicyclic and tricyclic terpenoids afforded oxidation products coming from epoxidation, to olefin degradation, methyne and methylene activation products. Probably, the most attractive result was the synthesis of the Magnus lactone 46, from the tricyclic ether 45, with 88% yield and 100% conversion.