23275-54-9

Basic information

• Product Name: 5-(4-tolyl)-1,2,4-oxadiazol-3-amine
• Synonyms: 5-(4-tolyl)-1,2,4-oxadiazol-3-amine
• CAS NO: 23275-54-9
• Molecular Weight: 175.19
• Mol File: 23275-54-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-tolyl)-1,2,4-oxadiazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-tolyl)-1,2,4-oxadiazol-3-amine(23275-54-9)
• EPA Substance Registry System: 5-(4-tolyl)-1,2,4-oxadiazol-3-amine(23275-54-9)

Safety Data

• Hazardous Substances Data: 23275-54-9(Hazardous Substances Data)

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 67095-88-9 N,N-diethyl-4-methylbenzimidamide 
• 51884-00-5 4-methylbenzoyl-cyanamide 

Downstream Products

• 33621-60-2 2-amino-5-(4-methylphenyl)-1,3,4-oxadiazole 

Relevant articles and documents

A diversified assembly of 1,2,4-oxadiazol-3-amines: Metallic thiophile catalyzed chemoselective one-pot reaction of aryl isothiocyanates, amidines/guanidines, and hydroxylamine

An efficient one-pot synthesis of 1,2,4-oxadiazol-3-amines from simple starting materials, isothiocyanates, amidines/guanidines, and hydroxylamine, is described. The reaction is facilitated by metallic-thiophile-assisted desulfurization of in situ formed amidino- or guanidinothiourea to give chemoselectively N-hydroxyguanidine intermediates that give exclusively various 1,2,4-oxadiazol-3-amines in good to excellent yields. The reaction mechanistic pathway may proceed through an intramolecular 5-exo-trig cyclization.