2328-26-9

Basic information

• Product Name: methyl (R)-2-phenylpropanoate
• CAS NO: 2328-26-9
• Molecular Weight: 164.204
• Mol File: 2328-26-9.mol
• Article Data: 49

Chemical Properties

• CAS DataBase Reference: methyl (R)-2-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (R)-2-phenylpropanoate(2328-26-9)
• EPA Substance Registry System: methyl (R)-2-phenylpropanoate(2328-26-9)

Safety Data

• Hazardous Substances Data: 2328-26-9(Hazardous Substances Data)

Upstream product

• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 67-56-1 methanol 
• 167476-41-7 1,1-bis(triethylsilyloxy)-2-phenylpropene 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 31508-44-8 2-phenylpropionic acid methyl ester 
• 103-82-2 phenylacetic acid 
• 101-41-7 benzeneacetic acid methyl ester 
• 492-37-5 hydratropic acid 
• 5445-17-0 Methyl 2-bromopropionate 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 98-80-6 phenylboronic acid 
• 72658-09-4 (E)-(1-methoxyprop-1-enyloxy)trimethylsilane 
• 144930-50-7 mesityl(phenyl)iodonium triflouromethanesulfonate 

Downstream Products

• 949560-41-2 (L)-2-phenylpropanehydrazide 
• 1350524-98-9 (L)-N-phenyl-2-(2-phenylpropanoyl)hydrazinecarbothioamide 
• 85020-76-4 methyl 2-deuterio-2-phenylpropionate 
• 582-22-9 (R)-2-phenylpropylamine 
• 14182-57-1 (R)-2-phenylpropionic acid amide 
• 1123-85-9 (+)-(R)-2-phenylpropanol 
• 73308-18-6 acetic acid (R)-(+)-2-phenyl-1-propanol ester 

Relevant articles and documents

Iron-catalysed enantioselective Suzuki-Miyaura coupling of racemic alkyl bromides

The first iron-catalysed enantioselective Suzuki-Miyaura coupling reaction has been developed. In the presence of catalytic amounts of FeCl2 and (R,R)-QuinoxP?, lithium arylborates are cross-coupled with tert-butyl α-bromopropionate in an enantioconvergent manner, enabling facile access to various optically active α-arylpropionic acids including several nonsteroidal anti-inflammatory drugs (NSAIDs) of commercial importance. (R,R)-QuinoxP? is specifically able to induce chirality when compared to analogous P-chiral ligands that give racemic products, highlighting the critical importance of transmetalation in the present asymmetric cross-coupling system.

Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System

A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides is described. This allows the arylation of silyl enol ethers to access enolizable α-arylated ketones in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation analysis. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides.

Synthesis method of (S)-2-aryl propionate compound

The invention discloses a synthesis method of a (S)-2-aryl propionate compound. The (S)-2-aryl propionate compound shown in the formula IV is obtained by taking a compound shown in a formula I and a compound shown in a formula II as raw materials and reacting under the conditions of a chiral ligand shown in a formula III, a nickel catalyst, a photocatalyst, a reducing agent and alkali under the condition of visible light. The method has the advantages of cheap and easily available raw materials, convenient generation, mild conditions, environmental protection and safety, the photocatalyst canbe recycled, the production cost is greatly reduced, the test operation is simple, less waste is generated, and the method can be developed into an industrial production method.