23291-98-7Relevant articles and documents
N-phenpropylcuclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
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, (2008/06/13)
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, —NR2 R3 or —NR4SO2R5; X is the linkage —(CH2)n— or —(CH2)q—O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.
Tricyclic aromatic ketones by cycliacylation of carboxylic acid derivatives of indan, tetralin, and benzosuberane
Isabelle, M. Elaine,Wightman, Robert H.,Avdovich, Hajro W.,Laycock, David E.
, p. 1344 - 1349 (2007/10/02)
The synthesis of a homologous series of new carboxylic acids substituted in the α-position of indan, tetralin, and benzosuberane is accomplished using an efficient general procedure.Cycliacylation of these acids and their corresponding β-isomers produces a complete series of tricyclic aromatic ketones.
