23360-92-1 Usage
Description
LEUROSINE, also known as Vinleurosine, is a complex dimeric alkaloid derived from the Vinca Rosea plant. It forms colorless crystals that are best purified through recrystallization from acetonitrile. LEUROSINE crystallizes with 8 moles of H2O and loses solvent when heated at 80-85°C. It is dextro-rotatory with [α]26D + n° (CHCI3). A crystalline sulfate of LEUROSINE is known, which has a melting point of 238-242°C (dec.) and [α]D 8.3° (MeOH). The N(b)-oxide of LEUROSINE is identical with pleurosine.
Uses
Used in Anticancer Applications:
LEUROSINE is used as an antitumor compound for its antineoplastic properties. It is derived from Vinca Rosea, a plant known for its cancer-fighting abilities. LEUROSINE plays a crucial role in the treatment of various types of cancer by targeting and inhibiting the growth of cancer cells.
Used in Pharmaceutical Industry:
LEUROSINE is used as an active pharmaceutical ingredient for the development of cancer treatments. Its unique properties and origin from a natural source make it a valuable component in the creation of new drugs and therapies aimed at combating cancer.
Used in Research and Development:
LEUROSINE is used as a research compound for studying the mechanisms of action and potential applications in cancer treatment. Its complex structure and alkaloid nature provide valuable insights into the development of new antineoplastic agents and understanding the interactions between natural compounds and cancer cells.
References
Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)
Check Digit Verification of cas no
The CAS Registry Mumber 23360-92-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,3,6 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 23360-92:
(7*2)+(6*3)+(5*3)+(4*6)+(3*0)+(2*9)+(1*2)=91
91 % 10 = 1
So 23360-92-1 is a valid CAS Registry Number.
InChI:InChI=1/C46H56N4O9/c1-8-42-16-12-18-50-20-17-44(37(42)50)30-21-31(34(55-5)22-33(30)48(4)38(44)46(54,41(53)57-7)39(42)58-26(3)51)45(40(52)56-6)23-27-24-49(25-43(9-2)36(27)59-43)19-15-29-28-13-10-11-14-32(28)47-35(29)45/h10-14,16,21-22,27,36-39,47,54H,8-9,15,17-20,23-25H2,1-7H3/t27-,36-,37+,38-,39-,42-,43+,44-,45+,46+/m1/s1
23360-92-1Relevant articles and documents
Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature
Asano, Mamiko,Harada, Kazuo,Yoshikawa, Tomoaki,Bamba, Takeshi,Hirata, Kazumasa
body text, p. 386 - 389 (2010/10/03)
We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of cath
ALKALOID PRODUCTION IN CATHARANTHUS ROSEUS (L.) G. DON CELL CULTURES, XV. SYNTHESIS OF BISINDOLE ALKALOIDS BY USE OF IMMOBILIZED ENZYME SYSTEMS
Kutney, James Peter,Boulet, Camille Andre,Choi, Lewis Siu Leung,Gustowski, Wlodzimierz,McHugh, Michael,et al.
, p. 621 - 628 (2007/10/02)
Affinity gel bound enzyme systems obtained from Catharanthus roseus cell cultures were employed to establish a high yielding enzymatic system for the coupling of catharanthine (1) and vindoline (2) to 3',4'-anhydrovinblastine (3) and leurosine (4).Long term enzymatic activity can be preserved by this technique, an aspect which may prove important in subsequent utilization of such systems in large scale production.
Biosynthesis of the indole alkaloids. Cell-free systems from Catharanthus roseus plants
Kutney,Choi,Honda,et al.
, p. 2088 - 2101 (2007/10/02)
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