23363-33-9

Basic information

• Product Name: 4''-(BENZYLOXYCARBONYL)-4''-DEMETHYLEPIPODOPHYLLOTOXIN
• Synonyms: 4''-(BENZYLOXYCARBONYL)-4''-DEMETHYLEPIPODOPHYLLOTOXIN
• CAS NO: 23363-33-9
• Molecular Formula: C₂₉H₂₆O₁₀
• Molecular Weight: 534.51
• Mol File: 23363-33-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4''-(BENZYLOXYCARBONYL)-4''-DEMETHYLEPIPODOPHYLLOTOXIN(CAS DataBase Reference)
• NIST Chemistry Reference: 4''-(BENZYLOXYCARBONYL)-4''-DEMETHYLEPIPODOPHYLLOTOXIN(23363-33-9)
• EPA Substance Registry System: 4''-(BENZYLOXYCARBONYL)-4''-DEMETHYLEPIPODOPHYLLOTOXIN(23363-33-9)

Safety Data

• Hazardous Substances Data: 23363-33-9(Hazardous Substances Data)

Upstream product

• 6559-91-7 4'-demethylepipodophyllotoxin 
• 501-53-1 benzyl chloroformate 
• 518-28-5 podofilox 

Downstream Products

• 127882-52-4 Carbonic acid benzyl ester 4-[(5R,5aR,8aR,9S)-9-(4-fluoro-phenoxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester 
• 127882-53-5 Carbonic acid benzyl ester 4-[(5R,5aR,8aR,9S)-9-(4-benzyloxy-phenoxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester 
• 131118-79-1 4-O-(3-O-acetyl-2-benzyloxycarbonylamino-2-deoxy-4,6-O-ethylidene-β-D-glucopyranosyl)-4'-O-benzyloxycarbonyl-4'-O-demethyl-4-epipodophyllotoxin 
• 131118-79-1 4-O-(3-O-acetyl-2-benzyloxycarbonylamino-2-deoxy-4,6-O-ethylidene-α-D-glucopyranosyl)-4'-O-benzyloxycarbonyl-4'-O-demethyl-4-epipodophyllotoxin 
• 131118-83-7 4'-O-benzyloxycarbonyl-4-O-(2-benzyloxycarbonylamino-3-O-chloroacetyl-2-deoxy-4,6-O-ethylidene-β-D-glucopyranosyl)-4'-O-demethyl-4-epipodophyllotoxin 
• 131118-83-7 4'-O-benzyloxycarbonyl-4-O-(2-benzyloxycarbonylamino-3-O-chloroacetyl-2-deoxy-4,6-O-ethylidene-α-D-glucopyranosyl)-4'-O-demethyl-4-epipodophyllotoxin 
• 134637-16-4 C₆₄H₆₁NO₁₆ 
• 111275-46-8 1-O-(3,4-di-O-acetyl-2-benzyloxycarbonylamino-2,6-dideoxy-β-D-glucopyranosyl)-4'-O-benzyloxycarbonyl-4'-O-demethyl-1-epipodophyllotoxin 

Relevant articles and documents

HUMAN TOPOISOMERASE II-TARGETING ORGANOPLATINUM COMPOUNDS

Some organoplatinum compounds have been synthesized. These organoplatinum compounds are designed to be human Topoisomerase II-targeting drugs.

The Catalytically Lignan-Activation-Based Approach for the Synthesis of (epi)-Podophyllotoxin Derivatives

Under the effect of a catalytic amount of Au(I) complex, 4-O-(2-cyclopropylethynyl)benzoyl-(epi)-podophyllotoxins, easily prepared via dehydrative condensation between (epi)-podophyllotoxin and ortho-cyclopropylethynylbenzoic acid, could efficiently coupl

Synthesis and evaluation of the apoptosis inducing and CT DNA interaction properties of a series of 4β-carbamoyl 4′-O- demethylepipodophyllotoxins

A series of carbamate derivatives of 4′-demethylepipodophyllotoxin have been synthesized, and their cytotoxicities against several human cancer cell lines, including HeLa, A549, HCT-8, and HL-60 cells, evaluated. Some of these compounds exhibited higher levels of cytotoxicity than the anticancer drug etoposide. 4β-4′-Demethylepipodophyllotoxin 1-(4-nitrophenyl) piperazinyl carbamate (19) was found to be the most potent compound of those synthesized in the current study, and induced cell cycle arrest in the G2/M phase in HeLa cells, which was accompanied by apoptosis. Furthermore, this compound activated the expression of Bax, p53 and caspase-3 in HeLa cells, leading to changes in the conformation of calf thymus DNA from the B-form to a more compact C-form.