234-70-8

Basic information

• Product Name: Imidazo[2,1-a]isoquinoline
• Synonyms: Imidazo[2,1-a]isoquinoline
• CAS NO: 234-70-8
• Molecular Formula: C₁₁H₈N₂
• Molecular Weight: 168.19
• Mol File: 234-70-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Imidazo[2,1-a]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[2,1-a]isoquinoline(234-70-8)
• EPA Substance Registry System: Imidazo[2,1-a]isoquinoline(234-70-8)

Safety Data

• Hazardous Substances Data: 234-70-8(Hazardous Substances Data)

Upstream product

• 1532-84-9 isoquinolin-1-ylamine 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 119-65-3 isoquinoline 
• 588-73-8 (Z)-β-bromostyrene 
• 6286-30-2 2,3-dibromo-3-phenylpropanoic acid 
• 100-52-7 benzaldehyde 
• 621-82-9 Cinnamic acid 
• 107-20-0 2-chloroethanal 
• 288-32-4 1H-imidazole 
• 536-74-3 phenylacetylene 
• 872-36-6 vinylene carbonate 
• 670-96-2 2-Phenylimidazole 
• 96-49-1 [1,3]-dioxolan-2-one 
• 1456-22-0 3-phenyl-4H-[1,2,4]oxadiazol-5-one 

Downstream Products

• 63111-65-9 1-benzyl-1H-imidazo[2,1-a]isoquinolin-4-ium bromide 

Relevant articles and documents

A general and efficient five-step one-pot procedure leading to nitrogen-bridgehead heterocycles containing an imidazole ring

A very simple annulation reaction was designed, allowing an imidazole moiety to be fused onto a range of pyridine-based derivatives. The methodology consists of an activation step via the formation of a pyridinium salt to increase the electrophilicity of

Rhodium-catalyzed reaction of 4-phenyl oxadiazolone and vinylene carbonate for synthesis of three types of isoquinoline heterocyclic rings

The invention discloses rhodium-catalyzed reaction of 4-phenyl oxadiazolone and vinylene carbonate for synthesis of three types of isoquinoline heterocyclic rings through temperature and additive control. The isoquinoline heterocyclic rings comprise 5-hydroxy-5,6-dihydro-3H-[1,2,4] oxadiazolo [3,4-a] isoquinoline-3-ketone, 3H-[1,2,4] oxadiazolo [3,4-a] isoquinoline-3-ketone, imidazo [2,1-a] isoquinoline, and derivatives thereof. The reaction involved in the invention is completed by a one-pot method, and the conversion from a 5-hydroxyisoquinoline ring to an isoquinoline ring and the change from an oxadiazolone ring to an imidazole ring can be realized under the control of an additive and temperature. The synthesis operation steps are simple, the atom economy is high, the reaction system is green and environment-friendly, the post-treatment operation is simpler, the implementation feasibility is high, and a foundation is laid for industrial production and wide application of the isoquinoline compound; and the synthesis method disclosed by the invention is convenient in reaction raw material source, mild in reaction condition, high in yield and wide in substrate application range.

One-Pot Synthesis of Imidazolyl Isoquinolines under a Palladium-Catalyzed C-H Activation/Annulation (CHAA) Reaction

A microwave-assisted Pd-catalyzed one-pot C-H activation/annulation (CHAA) protocol has been developed for the synthesis of imidazo[2,1-a]isoquinolines and benzo[4,5]imidazo[2,1-a]isoquinolines. Further N-alkylation for the preparation of a series of the

Synthesis of imidazo and benzimidazo[2,1-a]isoquinolines by rhodium-catalyzed intramolecular double C-H bond activation

The rhodium-catalyzed intramolecular direct arylation of imidazole and benzimidazole derivatives via double C-H bond activation is described. This approach provides new access to a wide range of imidazo and benzimidazo[2,1-a] isoquinoline derivatives in m