234-95-7

Basic information

• Product Name: pyrrolo[1,2-a]quinoxaline
• Synonyms: pyrrolo[1,2-a]quinoxaline
• CAS NO: 234-95-7
• Molecular Formula: C₁₁H₈N₂
• Molecular Weight: 168.19462
• EINECS: 205-942-8
• Mol File: 234-95-7.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 275.6°Cat760mmHg
• Flash Point: 120.5°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0.00504mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: pyrrolo[1,2-a]quinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: pyrrolo[1,2-a]quinoxaline(234-95-7)
• EPA Substance Registry System: pyrrolo[1,2-a]quinoxaline(234-95-7)

Safety Data

• Hazardous Substances Data: 234-95-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 52, p. 10751, 1996 DOI: 10.1016/0040-4020(96)00597-2

InChI:InChI=1/C11H8N2/c1-2-6-11-10(5-1)12-8-9-4-3-7-13(9)11/h1-8H

Upstream product

• 181464-30-2 2-aminomethyl-1-(2'-aminophenyl)pyrrole 
• 350829-07-1 1-[2-isocyanophenyl]-1H-pyrrole 
• 6025-60-1 2-(1H-pyrrol-1-yl)aniline 
• 209974-60-7 1-[(2-formylamino)phenyl]pyrrole 
• 1003-29-8 2-pyrrole aldehyde 
• 615-43-0 2-iodophenylamine 
• 615-36-1 2-bromoaniline 
• 1252799-13-5 ethyl (E)-3-[1-(2-aminophenyl)-1H-pyrrol-2-yl]prop-2-enoate 
• 67-56-1 methanol 
• 33265-60-0 1-(2-nitrophenyl)-1H-pyrrole 
• 30186-39-1 N-phenylpyrrole-2-carbaldehyde 
• 2206-27-1 dimethylsulfoxide-d6 
• 67-68-5 dimethyl sulfoxide 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 79323-08-3 5-benzoyl-4-cyano-4,5-dihydropyrrolo<1,2-a>quinoxaline 
• 79323-13-0 5-benzenesulfonyl-4-cyano-4,5-dihydropyrrolo<1,2-a>quinoxaline 
• 79323-17-4 5-(2-chloromethylbenzoyl)-4-cyano-4,5-dihydropyrrolo<1,2-a>quinoxaline 
• 79323-12-9 4-benzoylpyrrolo<1,2-a>quinoxaline 
• 79323-10-7 5-benzoyl-4-cyano-4-methyl-4,5-dihydropyrrolo<1,2-a>quinoxaline 

Related news

A New Approach to Pyrrolo[1,2-a]quinoxaline Derivatives09/30/2019

In the presence of base, ethyl 2,2-dihydropoly(per)fluoroalkanoate(2) reacted with N-phenacyl benzimidazole bromide(1a-1b),N-acetonyl benzimidazole bromide(1c) and N-ethoxycarbonylmethyl benzimidazole bromide(1d) in DMF to give pyrrolo[1,2-a]quinoxaline derivatives(3ae-3dg) respectively.detailed

Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK209/29/2019

Herein we describe the synthesis and properties of substituted phenylaminopyrrolo[1,2-a]quinoxaline-carboxylic acid derivatives as a novel class of potent inhibitors of the human protein kinase CK2. A set of 15 compounds was designed and synthesized using convenient and straightforward synthesis...detailed

Piperidine–iodine a dual system catalyst for synthesis of coumarin bearing pyrrolo[1,2-a]quinoxaline derivatives via a one-pot three-component reaction09/28/2019

The synthesis of 3-(4-alkyl-4,5-dihydropyrrolo[1,2-a]quinoxalin-4-yl)-2H-chromen-2-one derivatives by a three-component reaction of salicylaldehyde, β-keto esters, and 1-(2-aminophenyl)pyrrole using piperidine–iodine as a dual system catalyst is reported. Good yields, mild reaction conditions,...detailed

Relevant articles and documents

Transition-metal-free N-arylation: A general approach to aza-fused poly-heteroaromatics

A new and efficient method for the synthesis of various aza-fused poly-hetero aromatics has been described. This protocol includes an intermolecular condensation followed by metal-free base-promoted intramolecular C―N coupling reaction. The advantage of this one-pot transformation lies in the use of simple cyclic amidines-like compounds without prefunctionalization of the starting heterocycles.

Efficient copper-catalyzed annulation of 2-formylazoles with 2-haloanilines for the synthesis of pyrrole- and imidazole-fused quinoxalines

Promoted by CuI/2-hydroxybenzohydrazide catalytic system, a variety of pyrrole- and imidazole-fused quinoxalines have been efficiently one-pot synthesized from pyrrole-/imidazole-2-carboxaldehyde and 2-haloanilines in moderate to excellent yields. 2-Hydroxybenzohydrazide-promoted CuI-catalyzed one-pot annulation of pyrrole-/imidazole-2-carboxaldehyde with 2-haloanilines for the synthesis of pyrrolo[1,2-α]- and imidazo[1,2-α]quinoxalines under relatively mild conditions is described.

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N,N-dimethylformamide (DMF) as synthetic precursors contributing especially the methyl, acyl, and amino groups has played a significant role in heterocycle syntheses and functionalization. In this protocol, a wide range of pyrrolo/indolo[1,2-a]quinoxalines and quinazolin-4-ones were obtained in moderate to good yields by using elemental iodine without any metal or peroxides. We considered thatN-methyl andN-acyl of DMF participate and complete the reaction separately through different mechanisms, which displayed potential still to be explored of DMF.

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