2341-32-4

Basic information

• Product Name: Benzene, 1-(2-nitro-1-propenyl)-4-(trifluoromethyl)-
• Synonyms: 4-Bromo-b-methyl-b-nitrostyrene;p-Bromo-b-methyl-b-nitrostyrene
• CAS NO: 2341-32-4
• Molecular Formula: C10H8F3NO2
• Molecular Weight: 231.174
• Mol File: 2341-32-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2-nitro-1-propenyl)-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2-nitro-1-propenyl)-4-(trifluoromethyl)-(2341-32-4)
• EPA Substance Registry System: Benzene, 1-(2-nitro-1-propenyl)-4-(trifluoromethyl)-(2341-32-4)

Safety Data

• Hazardous Substances Data: 2341-32-4(Hazardous Substances Data)

Upstream product

• 21886-16-8 2-nitro-1-<4-(trifluoromethyl)phenyl>-1-propanol 
• 142839-96-1 Acetic acid 2-nitro-1-(4-trifluoromethyl-phenyl)-propyl ester 
• 135711-49-8 Butyl-[2-nitro-1-(4-trifluoromethyl-phenyl)-propyl]-amine 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 79-24-3 Nitroethane 

Downstream Products

• 29865-58-5 1-(2-nitropropyl)-4-(trifluoromethyl)benzene 
• 1260519-56-9 2-methyl-3-(4-(trifluoromethyl)phenyl)quinoxaline 
• 1365761-37-0 [1-methyl-2-(4-trifluoromethyl-phenyl)-ethyl]-carbamic acid ethyl ester 
• 84580-99-4 (R)-α-(p-(trifluoromethyl)benzyl)ethylamine 
• 84580-04-1 (S)-α-(p-(trifluoromethyl)benzyl)ethylamine 
• 1352411-22-3 N-[2-(4'-trifluoromethylphenyl)-1-methylethyl]-2-methoxyacetamide 
• 1351781-77-5 (R)-N-[2-(4'-trifluoromethylphenyl)-1-methylethyl]-2-methoxyacetamide 
• 142840-11-7 -(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-<4-(trifluoromethyl)phenyl>cyclopent<1,2>oxazine N-oxide 
• 1626-74-0 1-methyl-2-(4-trifluoromethyl-phenyl)-ethylamine 

Relevant articles and documents

Discovery of a PCAF Bromodomain Chemical Probe

The p300/CBP-associated factor (PCAF) and related GCN5 bromodomain-containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine-based L-45 (dubbed L-Moses) as the first potent, selective, and cell-active PCAF bromodomain (Brd) inhibitor. Synthesis from readily available (1R,2S)-(?)-norephedrine furnished L-45 in enantiopure form. L-45 was shown to disrupt PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-45 with the homologous Brd PfGCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. Compound L-45 shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell-permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use.

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.

Inter- and Intramolecular Cycloadditions of Nitroalkenes with Olefins. 2-Nitrostyrenes

Aromatic nitroalkenes 9 - 12 underwent Lewis acid catalyzed cycloadditions with various cyclic alkenes to afford high yields of nitronates 25 - 30 with exclusive anti selectivity.Hammett studies helped to further delineate the role of the Lewis acid.Reaction of nitroalkenes 8 and 10 with various cyclic dienes in the presence of a Lewis acid demonstrated the ability of nitroalkenes to behave as dienes in cycloadditions.The major products were the syn diastereomers which arise from an endo-folded transition structure.Finally, intramolecular cycloaddition of 36 - 39 allowed a correlation between the stereochemical course of the reaction and positions of sp2 centers in the tether to be addressed.