23418-90-8Relevant articles and documents
Stereoselective Suzuki coupling reaction of an α-bromo-α-fluoro-β-lactam
Tarui, Atsushi,Miyata, Erina,Tanaka, Ayumi,Sato, Kazuyuki,Omote, Masaaki,Ando, Akira
, p. 55 - 58 (2015)
A new strategy has been developed for the synthesis of α-aryl-α-fluoro-β-lactams via the Suzuki cross-coupling of α-bromo-α-fluoro-β-lactam with a range of different aryl-(9-BBN) reagents. This method provides facile access to multisubstituted α-fluoro-β-lactams in a diastereoselective manner. The synthetic utility of α-bromo-α-fluoro-β-lactam has been demonstrated by the arylation of α-bromo-α-fluoro-β-lactam.