23432-42-0

Basic information

• Product Name: 4-HYDROXY-6-NITROQUINOLINE
• Synonyms: 4-HYDROXY-6-NITROQUINOLINE;Nsc78445;6-Nitroquinolin-4-ol
• CAS NO: 23432-42-0
• Molecular Formula: C9H6N2O3
• Molecular Weight: 190.15554
• EINECS: -0
• Mol File: 23432-42-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 325 °C
• Boiling Point: 362.6 °C at 760 mmHg
• Flash Point: 173.1 °C
• Appearance: /
• Density: 1.419 g/cm³
• Vapor Pressure: 1.91E-05mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.86±0.40(Predicted)
• CAS DataBase Reference: 4-HYDROXY-6-NITROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-6-NITROQUINOLINE(23432-42-0)
• EPA Substance Registry System: 4-HYDROXY-6-NITROQUINOLINE(23432-42-0)

Safety Data

• Hazardous Substances Data: 23432-42-0(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-6-nitroquinoline is a chemical compound that belongs to the class of quinoline derivatives. It is characterized by a hydroxyl group (-OH) and a nitro group (-NO2) attached to a quinoline ring structure. 4-HYDROXY-6-NITROQUINOLINE is widely used in organic synthesis and pharmaceutical research due to its unique structural features and potential biological activities. Its versatile nature makes it valuable in the development of new drugs, agrochemicals, and materials. Additionally, it is used as a precursor in the preparation of various biologically active compounds and can also act as a chelating agent in coordination chemistry.

InChI:InChI=1/C9H6N2O3/c12-9-3-4-10-8-2-1-6(11(13)14)5-7(8)9/h1-5H,(H,10,12)

Upstream product

• 611-36-9 quinolin-4-ol 
• 7664-93-9 sulfuric acid 
• 529-37-3 4(1H)-quinolinone 
• 7697-37-2 nitric acid 
• 15568-92-0 5-(N-phenyl)-aminomethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 68771-39-1 1-methyl-6-nitro-1H-quinolin-4-one 
• 56717-02-3 6-amino-quinolin-4-ol 
• 13675-94-0 4-chloro-6-nitroquinoline 
• 874499-33-9 3,6-dinitro-quinolin-4-ol 
• 1085192-91-1 4-chloroquinolin-6-amine 
• 860195-53-5 4-bromo-6-nitroquinoline 

Relevant articles and documents

The discovery of quinoline derivatives, as NF-κB inducing kinase (NIK) inhibitors with anti-inflammatory effects in vitro, low toxicities against T cell growth

NIK is a critical regulatory protein of the non-classical NF-kB pathway, and its dysregulated activation has been proved to be one of the pathogenic factors in a variety of autoimmune diseases and inflammatory diseases. Nevertheless, its corresponding dev

AKT3 MODULATORS

Compounds of Formula la, lb, or Ic, (Ia); (Ib); or (Ic), are described, where the various substituents are defined herein. The compounds can modulate a property or effect of Akt3 in vitro or in vivo, and can also be used, individually or in combination with other agents, in the prevention or treatment of a variety of conditions. Methods for synthesizing the compounds are described. Pharmaceutical compositions and methods of using these compounds or compositions, individually or in combination with other agents or compositions, in the prevention or treatment of a variety of conditions are also described.

QUINOLINE-BASED COMPOUNDS AND METHODS OF INHIBITING CDK8/19

Disclosed herein are quinoline-based compounds and method for inhibiting CDK8 or CDK19 for the intervention in diseases, disorders, and conditions. The quinoline-based composition comprise substituents at quinoline ring positions 4 and 6, wherein the substituent at position 4 is selected from a substituted or unsubstituted arylalkylamine or a substituted or unsubstituted arylhetrocyclylamine. Pharmaceutical compositions comprising the substituted qunioline compositions, methods of inhibiting CDK8 or CDK19, and methods of treating CDK8/19-associated diseases, disorders, or conditions are also disclosed.