23432-44-2

Basic information

• Product Name: 4-HYDROXY-8-METHYLQUINOLINE
• Synonyms: 8-METHYL-4-QUINOLINOL;8-METHYL-4(1H)-QUINOLINONE;8-METHYL-QUINOLIN-4-OL;4-HYDROXY-8-METHYLQUINOLINE;8-Methylquinolin-4(1H)-one;8-Methylquinolin-4-ol, 4-Hydroxy-8-methyl-1-azanaphthalene
• CAS NO: 23432-44-2
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Mol File: 23432-44-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 213-215
• Boiling Point: 326.8 °C at 760 mmHg
• Flash Point: 151.4 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 0.000111mmHg at 25°C
• Refractive Index: 1.666
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.47±0.40(Predicted)
• CAS DataBase Reference: 4-HYDROXY-8-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-8-METHYLQUINOLINE(23432-44-2)
• EPA Substance Registry System: 4-HYDROXY-8-METHYLQUINOLINE(23432-44-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 23432-44-2(Hazardous Substances Data)

Usage

General Description

4-HYDROXY-8-METHYLQUINOLINE, also known as 8-methyl-4-quinolol, is an organic compound that belongs to the quinoline family. It is a yellowish crystalline powder that is soluble in organic solvents and has a characteristic odor. This chemical is commonly used as an intermediate in the production of various pharmaceuticals, including antimalarial and antifungal drugs. It is also utilized in the synthesis of dyes and as a chelating agent for metal ions. Additionally, 4-HYDROXY-8-METHYLQUINOLINE has potential applications in the field of analytical chemistry, particularly as a reagent for the determination of certain metal ions in solution. However, it is important to handle this chemical with care, as it may be harmful if ingested, inhaled, or absorbed through the skin.

InChI:InChI=1/C10H9NO/c1-7-3-2-4-8-9(12)5-6-11-10(7)8/h2-6H,1H3,(H,11,12)

Upstream product

• 36053-94-8 8-methyl-2,3-dihydro-1H-quinolin-4-one 
• 35966-17-7 4-hydroxy-8-methyl-quinoline-3-carboxylic acid 
• 25253-09-2 5-{[(2-methylphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 77156-75-3 4-hydroxy-8-methyl-quinoline-3-carboxylic acid ethyl ester 
• 19146-73-7 diethyl 2-((o-tolylamino)methylene)malonate 

Downstream Products

• 611-32-5 8-methylquinoline 
• 18436-73-2 4-chloro-8-methylquinoline 
• 1621082-94-7 4-methyl-N-(2-methyl-6-{1-[(4-methylphenyl)sulfonyl]-1Hpyrazol-3-yl}phenyl)benzenesulfonamide 
• 68500-35-6 4-hydrazino-8-methyl-quinoline 
• 1621083-00-8 N-{2-methyl-6-[1-(phenylsulfonyl)-1H-pyrazol-3-yl]phenyl}benzenesulfonamide 
• 1082748-36-4 C₁₀H₁₁N₃ 
• 36075-68-0 4-bromo-8-methylquinoline 
• 1593934-90-7 methyl 8-methylquinoline-4-carboxylate 
• 816448-09-6 8-methylquinoline-4-carboxylic acid 

Relevant articles and documents

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.