23434-37-9

Basic information

• Product Name: Heptanoic acid, 7-[[(phenylmethoxy)carbonyl]amino]-
• CAS NO: 23434-37-9
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.336
• Mol File: 23434-37-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Heptanoic acid, 7-[[(phenylmethoxy)carbonyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Heptanoic acid, 7-[[(phenylmethoxy)carbonyl]amino]-(23434-37-9)
• EPA Substance Registry System: Heptanoic acid, 7-[[(phenylmethoxy)carbonyl]amino]-(23434-37-9)

Safety Data

• Hazardous Substances Data: 23434-37-9(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 929-17-9 7-aminoheptanoic acid 
• 673-66-5 7-amino-heptanoic acid lactam 

Downstream Products

• 92120-88-2 7,7'-bis(benzyloxycarbonylamino)-N,N'-octamethylenediheptanamide 
• 66888-28-6 7-(benzyloxycarbonylamino)heptanoyl chloride 
• 169464-09-9 methyl N-Cbz-N-methyl-7-aminoheptanoate 
• 108257-23-4 (6-{[(2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-hexyl)-carbamic acid benzyl ester 
• 141367-25-1 N,N-bis<7-<<(benzyloxy)carbonyl>amino>heptanoyl>-1,6-hexanediamine 

Relevant articles and documents

Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate

Epidermal growth factor receptor inhibitors (EGFR-TKIs) represent a class of compounds widely used in anticancer therapy. An increasing number of studies reports on combination therapies in which the block of the EGFR-TK activity is associated with inhibition of its downstream pathways, as PI3K-Akt. Sulforaphane targets the PI3K-Akt pathway whose dysregulation is implicated in many functions of cancer cells. According to these considerations, a series of multitarget molecules have been designed by combining key structural features derived from an EGFR-TKI, PD168393, and the isothiocyanate sulforaphane. Among the obtained molecules 1-6, compound 6 emerges as a promising lead compound able to exert antiproliferative and proapoptotic effects in A431 epithelial cancer cell line by covalently binding to EGFR-TK, and reducing the phosphorylation of Akt without affecting the total Akt levels.

Chemoselective reductive nucleophilic addition to tertiary amides, secondary amides, and N-methoxyamides

As the complexity of targeted molecules increases in modern organic synthesis, chemoselectivity is recognized as an important factor in the development of new methodologies. Chemoselective nucleophilic addition to amide car-bonyl centers is a challenge because classical methods require harsh reaction conditions to overcome the poor elec-trophilicity of the amide carbonyl group. We have successfully developed a reductive nucleophilic addition of mild nu-cleophiles to tertiary amides, secondary amides, and N-methoxyamides that uses the Schwartz reagent [Cp2ZrHCl]. The reaction took place in a highly chemoselective fashion in the presence of a variety of sensitive functional groups, such as methyl esters, which conventionally require protection prior to nucleophilic addition. The reaction will be applicable to the concise synthesis of complex natural alkaloids from readily available amide groups.

Bridged isocytosine-adenosine compounds: Synthesis and antibacterial evaluation

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