23434-40-4

Basic information

• Product Name: Octanoic acid, 8-[[(phenylmethoxy)carbonyl]amino]-
• CAS NO: 23434-40-4
• Molecular Formula: C16H23NO4
• Molecular Weight: 293.363
• Mol File: 23434-40-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Octanoic acid, 8-[[(phenylmethoxy)carbonyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Octanoic acid, 8-[[(phenylmethoxy)carbonyl]amino]-(23434-40-4)
• EPA Substance Registry System: Octanoic acid, 8-[[(phenylmethoxy)carbonyl]amino]-(23434-40-4)

Safety Data

• Hazardous Substances Data: 23434-40-4(Hazardous Substances Data)

Upstream product

• 1074-51-7 cyclooctanone oxime 
• 501-53-1 benzyl chloroformate 
• 1002-57-9 8-Aminooctanoic acid 

Downstream Products

• 108257-18-7 8-Benzyloxycarbonylamino-octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 195302-72-8 (S)-1-[(R)-2-(8-Benzyloxycarbonylamino-octanoylamino)-4-phenyl-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 102522-32-7 tert-butyl 8-aminooctanoate 
• 1448321-04-7 benzyl N-[8-oxo-8-(prop-2-enylamino)octyl]carbamate 
• 1448321-33-2 C₃₅H₅₉N₅O₇ 
• 1000005-24-2 C₃₅H₆₁N₅O₆ 
• 1448321-36-5 benzyl (8-(4-((tert-butoxycarbonyl)imino)-2-oxo-1,3,5-triazacyclotridecan-1-yl)octyl)carbamate 
• 1448321-22-9 C₃₂H₄₉N₅O₇ 
• 1448321-21-8 C₃₁H₄₇N₅O₇ 
• 1448321-20-7 C₃₆H₅₁N₅O₆ 
• 1448321-17-2 C₃₅H₄₉N₅O₆ 
• 1448321-16-1 benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1⁽¹³⁾,9,14,16-tetraen-7-yl]octyl]carbamate 
• 1448321-15-0 C₃₄H₅₃N₅O₇ 
• 1448321-13-8 C₃₃H₅₁N₅O₇ 

Relevant articles and documents

Novel macrocyclic amidinoureas: Potent non-azole antifungals active against wild-type and resistant Candida species

Novel macrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agents against wild-type and fluconazole resistant Candida species. Macrocyclic compounds 11 and 18 were synthesized through a convergent approach using as a key step a ring-closing metathesis macrocyclization reaction, whereas compounds 25 were obtained by our previously reported synthetic pathway. All the macrocyclic amidinoureas showed antifungal activity toward different Candida species higher or comparable to fluconazole and resulted highly active against fluconazole resistant Candida strains showing in many cases minimum inhibitory concentration values lower than voriconazole.

LUMINALLY-ACTING N-(PIPERIDIN-4-YL)BENZAMIDE DERIVATIVES

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein m, R1, R2, R3, R4, R5, R6, X1, X2, X3 and X4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with the 5-HT4 receptor.

Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol

In the last ten years, we identified and developed a new therapeutic class of antifungal agents, the macrocyclic amidinoureas. These compounds are active against several Candida species, including clinical isolates resistant to currently available antifungal drugs. The mode of action of these molecules is still unknown. In this work, we developed an in-silico target fishing procedure to identify a possible target for this class of compounds based on shape similarity, inverse docking procedure and consensus score rank-by-rank. Chitinase enzyme emerged as possible target. To confirm this hypothesis a novel macrocyclic derivative has been produced, specifically designed to increase the inhibition of the chitinase. Biological evaluation highlights a stronger enzymatic inhibition for the new derivative, while its antifungal activity drops probably because of pharmacokinetic issues. Collectively, our data suggest that chitinase represent at least one of the main target of macrocyclic amidinoureas.